# Advance Asymmetrics, Inc. — Hazardous Materials Safety Interpretation - **operation:** document - **citation:** 09-0119 - **title:** Advance Asymmetrics, Inc. — Hazardous Materials Safety Interpretation - **source type:** guidance - **agency:** Pipeline and Hazardous Materials Safety Administration - **status:** guidance - **official:** true - **published on:** 2009-06-19 - **effective on:** Not available - **summary:** 09-0119 response to Advance Asymmetrics, Inc. concerning 172.101, 173.22. - **machine formats:** - **json:** https://regulus.evalyn.ai/document/phmsa-interpretation-09-0119.json - **markdown:** https://regulus.evalyn.ai/document/phmsa-interpretation-09-0119.md - **app url:** https://regulus.evalyn.ai/document/phmsa-interpretation-09-0119 - **source url:** https://www.phmsa.dot.gov/sites/phmsa.dot.gov/files/legacy/interpretations/Interpretations/2009/090119.pdf **body:** <<>> U.S. Department of Transportation Pipeline and Hazardous Materials Safety Administration JUN 1 9 2009 1200 New Jersey Ave, S.E. Washington, D.C. 20590 Mr. Lawrence D. Rutledge Advance Asymmetrics, Inc. 2 13 East White Street Millstadt, IL 62260- 1543 Ref. No. 09-0 1 19 Dear Mr. Rutledge: This responds to your May 1,2009 letter requesting an interpretation of your procedure for classifying and describing di-tert-Butyldicarbonate under the Hazardous Materials Regulations (HMR; 49 CFR Parts 17 1 - 1 80). Under 8 173.22, it is the shipper's responsibility to class and describe a hazardous material. This Office does not perform that function. Your analysis of the physical and chemical properties of di-tert-Butyldicarbonate and your procedure for determining the classification, packing group assignment, and appropriate shipping description provides for a reasonable conservative conclusion. Your understanding is correct that the material is a solid as defined in accordance with 8 171.8 and should be described as a solid. However, we are concerned that using a shipping description that identifies the material as a solid when the material may be shipped as a liquid may not convey appropriate information to transport workers and emergency responders. To ensure that complete information concerning the material is provided, you may add the qualifying word "molten" to the shipping description in accordance with 8 172.101 (c)(16). Alternatively, you may include additional information on the shipping paper to indicate the material may be in a liquid state during the normal course of transportation. Note that when the authorized packaging associated with the shipping description for material is inappropriate for the physical state of the material during transport, 8 172.10 1 (i)(4) should be used to determine the appropriate packaging. I hope this information is helpful. If you have further questions, please do not hesitate to contact this office. Charles E. Betts 0 e of Hazardous Materials Standards hhief, Standards Development <<>> Advanced Asymmetries, Inc. 21 3 East White street-. Millstadt, IL 62260-1543 Phone 1-61 8-476-7408 or 1-888-330-6324 Fax 1-61 8-476-7408 or 1-888-704-31 33 3172- 10 1 Steve Hwang Office of Hazardous Materials Safety Pipeline and Hazardous Mcterials Safety Administration Attn: PHH- 10, U.S. Department of Transportation. East Building 1200 New Jersey Avenue, SE. Washington, DC 20590-000 1 Dear Mr. Hwang: I represent a small research chen~icals supplier attempting to classify a chemical for shipping. We generally have no problems doing this. after which we double check our work by verifying our classification against the classifications in a number of other company's MSDSs. In this case however we have encountered a problem with this protocol and would like to receive an official interpretation on our classitication procedure. Attached piease find four of our competitor's MSDSs for di-tert-Butyldicarbonate. As you will see, they have each classiiied the compoc~nd differently, as IJN2929, UN2930,1JN28 1 1, and UN 1325. The difference is important to us as: it will affect the container sizes which we can list and ship ii-I our catalog. 'I'hz nortnal procedure suggested to us is to siinply accept our supplier's classification. In this case however, our supplier is the one wlio classifies the product a UN 1325 which is both the lowest hazard and, in our opinion. the least defensible classification. We are unable to obtain a clarificalion fi-on1 them as they have discontinued this product. Our problem with the classification arises from the fact that much of the data required for proper classification is not available at the exact physical conditions required for analysis. As a result, we have made calculations of the expected values hy various means. We are unclear as to the exact extent to which such a calciilation is permissable in making classification. We would like our analysis as providcd below to be reviewed with particular note to the approximations and calculated physical and toxicological properties. We are most interested in an indication of whether these calculations and the conclusions derived from them may be considered valid. If so, we would appreciate some guidance as to the limits of these methods. The enclosed MSDSs sl~ould have all the inforn~ation required to evaluate our assignment procedure. Please note !hat the MSIIS from Acros (Maybridge) appears to have two errors in it: B First it reports of a vapor pressure of 0.5 nirnHg at 37 "C. 'This value appears nowhere else that I can fit~d arid appears to be either a typo of the correct value of 57 "C or an error caused by copying their flash point temperature of 37 "C. The value of 56-57 "C at 0.5 1nm3g is consistent across all other vendors and is consistent with a nomograph-based prediction from the value of 70 "C at 1 mm Hg reported in the Sigma MSDS. All other physical and hazard data is co~isistent across all MSDSs. <<>> a Second it correctly reports a correct LCSo of 100 mg / m' / 4 hour then notes a 1 hour LC50 of 400 nlg / n13 can be approximated. This appears to be twice the correct value according to the approximations allowed by regulation. One problem for classification is that no boiling point or vapor pressure can be found for temperatures below 57 "C while classification requires this value at 20 "C. The required value was estimated in the followii1g way: a Known vapor pressures are I min Hg (1.33 hPa) @ 70 "C (only a single reference) and 0.5 rnm Hg 56 "C (which is used in almost everyone's MSDS). Determination of a boiling point/vapor pressure at 20 "C was calculated using the boiling point calculator at http://~vww.trimen.pl/witek/calculators/wzenie.html. a The calculator's validity was checked by using it to predict some known boiling points and enthalpies of vaporization and found to be correct within a few degrees of temperature or several percent on enthalpy of vaporization, values which are within the expected experimental error. a 'The calculator is "unfi-iendly" regarding the number of decimal places provided. The mathematics however are such than if a 1000 times too large vapor pressure is input, a 1000 time too large vapor pressure will be output, however the calculator will in this case provide a larger number of significant figures in the result. All calculations were done in this way to obtain a sufficient number of significant figures, then double-checked by calculation using the .'iminflated" values and found correct. a Boiling point calculation involves three data points - the boiling point at two pressures arid the enthalpy of vaporization. Knowledge of any two allows prediction of the other. Additionally knowledge of two boiling points allows prediction of a third. o Using the known boiling points at 57 OC and 70 "C, an eilthalpy of vaporization of 46.5 kJ/mol and a vapor pressure of 0.062 nlm Hg at 20 "C. o A calculated enthalpy of vaporization based on molecular modeling of 47.26 kJ/mol was located. Using the same calculator with this enthalpy for calibration and using the 56 "C boiling point provides a vapor pressure of 0.060 rnin Hg at 20 "C. o A calculated vapor pressure based on molecular modeling of 0.049 mm Hg at 25 "C was also located. Using the enthalpy of 47.26 kJ/mol for calibration, this predicts a vapor pressure of 0.035 mm Hg at 20 "C. a Therefore calculations involviilg a vapor pressure will be made using the highest (0.062 mn Hg) and the lowest (0.035 mm Hg) values and the worst-case assumed. It is worth noting that the predictions of ca. 0.06 mn1 Hg are based on an assumption of a liquidlgas equilibrium. At 20 "C the product is in fact a solid and the vapor pressure may reasonably be expected to be less than this amount. Two final complications need to be addressed before making the final assignment: a The product melting point is 22-24 "C. Products melting above 20 "C are considered solids for classification purposes, therefore this product is a solid. If shipped at a <<>> temperature above 22 "C, the proper shipping name should include the word "molten" (but for classiiicatioi~ and labeling purposes is still considered a solid). Note however that the regulations require the initial melting point to be above 20 "C to be considered a solid. As the product ages and becomes impure, the melting point will depress and eventually fall into the liquid category. Therefore we must acknowledge that some shipments of this product may in fact be liquid according to this definition. Accordingly we will present two different classifications, depending on whether the given sample is to be considered a liquid or a solid. a Illhalation hazards must be considered for dusts (as solids), mists/aerosols (as liquids) and and vapors (either form). Again, we will present independent classifications for both solid " and liquid forms. Our classification for this product is as follows. I regret that we are unable to provide citations to DOT regulations. All citations are to 50"' Edition IATA (2009). I trust you have access to a cross reference to specific DOT regulations. 1) First the product is classified based on its flammability, in both the solid and liquid forms: a The product has a ilash point of 99 O F 1 37 "C, a temperature at which it would be a liquid. 'This corresponds to PG 111. Decomposition however leads to tert-butanol as a product which has a flash point of 1 1 "C and which, in sufficient quantity, could reduce the flash point to the extent that it met the requirements for PG 11, an effect which would depend on the exact level of impurity. Until a flash point is measured on an defined impure sample, we will use a working classification of PG I1 based on the flammability characteristic when the product is a liquid by regulations. a There is no appropriate information regarding the solid flammability tests. The product clearly does not meet the classification of PG I. Local tests and experience suggest the solid classification of PG 111, however at our current level of experience we do not wish to rely on those tests. Again until more accurate tests are performed we will use a working classification of PG I1 based on the flammability characteristic when the product is a solid by regulations. 2) Oral (>5000 mglkg) and dermal (>2000 mglkg) toxicities imply no toxic hazard by those routes and are valid for both solid and liquid forms. 3) Inhalation hazard classif7cation must consider both dust/mist and vapor. We have a citation for a LCso of 100 mg / mi / 4 hour but can not find any note indicating whether it is a dustimist or a vapor exposure. The calculated vapor pressure at 20 OC would produce a saturated vapor of 794 mg / m3, nearly eight times this value. It is reasonable therefore to assume this is a vapor measurement. None-the-less, exposures will be considered for dust. mist, and vapor modes of inhalation exposure to provide an additional margin of safety by shipping based on the most restrictive result. 3.6.1 S.3.2 states that the hazard is to be calculated based on LCso 1 1 hour but when only the 4 hour number is available, it inay be used after doubling. The available number of 100 nlg / m: is a 3 ]lour exposure, so a working inhalation toxicity of 200 ing / n1' shall be used. 4) Accordiilg to 3.6.1.5.3 a solid compound need only be tested if at least 10% (by mass) of the total is likely to be dust. In this case. the compound is packaged as a melt then allowed to freeze before shipping. 11 is a single mass so there is no potential for any significant dust, even were the <<>> container to be shattered. Therefore, inhalation toxicity by dust need not be considered. When the product is a solid, according to 3.6.1.5.3 its hazards as a liquid (i.e. Mist/aerosol) need not be considered. 5) According to 3.6.1.5.3 a liquid need only be tested if a mist or aresols is likely to be generated by leakage of the transport containment. In this case however the compound is shipped unpressurized. The vapor pressure is quite low (under 111000 of an atmosphere) so no mist or aerosol would be generated by boiling at the reduced pressure of a flight. Again, therefore, inhalation toxicity by mist need not be considered. 6) In the case of either a solid or a liquid however, inhalation hazard by vapor is equally valid. There are two tests, both of which inust confirm the hazard for proper classification. LATA regulations ask for toxicity in terms of mL / m! Since we are deaIing with vapors, I understand this to mean mL of conlpound in the vapor phase per cubic meter of air. Using Ideal Gas Law and assuming a temperature of 20 "C (specified by 3.6.1.5.3.2), 200 mg 1 m q s 22 mL of vapor. According to table 3.6.B, 22 < 1000, so this is PG I by that test. Tlle value of V (see note 1 on p 106, below table 3.6.B) inust also be calculated and compared to n~ultiples of the LC5,, vapor co~~centration. V for the two vapor pressures of 0.062 and 0.049 mm Hg are 81 and 63. Both of the V values are less than 10 x LCso. Failure ofthis second test meails the product is not PG 11. The two values are between -37% and 29% of [he required threshold which, given the closeness of the calibration points and multiple calculations, is judged to be inore than an adequate margin for error alid far higher than the calculation uucertainties. Additionally UN3384 requires the same LCso and V thresholds as the PG I test, so this is also not a proper classification. The test for PC; 11 only requires V be greater than LCSo. Both V values are greater than LCio so on that measure our conclusion is PG I1 according to inhalation toxicity Based on these considerations. our classiiication is UN2930, Toxic solid, Flammable, Organic, n.0.s.. 6.1(3. I), Packing Group I1 in those cases where the product is sufficiently pure that its initial melting point is greater than 20 "C, and UN2930, Toxic liquid, Flammable, Organic, n.o.s., 6.1(3), Packing Group I1 in those cases where the pl-oduct is sufficiently impure that its initial melting point is 20 "C or less. Please let me know if you concur with this classification. If additional clarifications are required, I may be reached at 61 8-476-3920 or at larry@4chiral.com. Best Regards, /+- a - Lawrence D. Rutledge Advanced ~ s ~ m r n e t ~ - i c s . Inc . <<>> MAYBRIDGE Material Safety Data Sheet Di-tert-butyl dicarbonate MSDS# 68225 Section 1 - Chemical Product and Con~pany ldentification MSDS Di-tert- butyl dicarbonate Name: Numbers: Synonyms: 1 8977-0000, 1 8977-0050, 18977- 1 000, 1 8977-5000, 19467-0000, 19467-0 100, 19467-0250, 19467- 0500, 19467- 1000, 19467-5000,61275-0 100,6 1275-0250,6 1 275-0500,6 1275- 1000.6 1275-5000, SBO 1692DA, SBOl692EA, SBO 1692EE, SBO 169222 Di-tert-butyl pyrocarbonate; DIBOC; BOC anhydride. Maybridge Company Identification: Trevillett, Tintagel Cornwall, England PL34 OHW For information in the US, call: 800-ACROS-0 1 For iriformation in Europe, call: +32 1457 5211 Emergency Number, Europe: +32 1 4 5 7 5 2 9 9 Emergency Number US: 20 1-796-7100 CHEMTREC Phone Number, US: 800-424-9300 CHEMTREC Phone Number, Europe: 703-527-3887 Section 2 - Composition, Information on Ingredients CAM: Chemical Name: %: EINECS#: 24424-99-5 Di- tert- butyl dicarbonate 97+ 246- 240- 1 Hazard Symbols: T+ Risk Phrases: 1 1 26 36/37/38 43 Section 3 - Hazards Identification EMERGENCY OVERVIEW Danger! Flammable solid. May be fatal if inhaled. May cause sensitization by skin contact. Causes eye, skin, and respiratory tract irritation. Target Organs: Central nervous system. respiratory system, eyes, skin. Potential Health Effects Eye: Causes eye irritation. Skin: May cause skin irritation. May be harmful if absorbed through the skin. May cause sensitization by skin contact. Tngestion: May cause irritation of the digestive tract. May be harmful if swallowed. Inhalation: May be fatal if inhaled. Causes respiratory tract irritation. Chronic: Repeated or prolonged exposure may cause allergic reactions in sensitive individuals. Section 4 - First Aid Measures <<>> Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower . Eyes: eyelids. Get niedical aid. Get medical aid. Immediately flush skin with plenty of water for at least 15 minutes while removing Skin: contaminated clothing and shoes. Ingestion: Do not induce vomiting. Get medical aid. POISON material. If inhaled, get medical aid immediately. Remove victim to fresh air. If not breathing, give Inhalation: Notes to Physician: artificial respiration. If breathing is difficult, give oxygen. Treat symptomatically and supportively. Section 5 - Fire Fighting Measures 4 s in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHANIOSH (approved General Information: or equivalent), and full protective gear. Vapors may form an explosive mixture with air. Vapors can travel to a source of ignition and flash back. Use water spray to keep fire-exposed containers cool. Containers may explode in the heat of a fire. Flammable solid. Extinguishing Use water spray to cool fire-exposed containers. Use foam, dry chemical, or carbon dioxide. Water may Media: be ineffective. Autoignition Temperature: 460 deg C ( 860.00 deg F) Flash Point: 37 deg C ( 98.60 deg F) Explosion Not available Limits: Lower: Explosion Not available Limits: Upper: NFPA Rating: health: 4; flammability: 3; instability: 1 ; Section 6 - Accidental Release Measures General Information: Spills/Leaks: Use proper personal protective equipment as indicated in Section 8. Wear a self contained breathing apparatus and appropriate personal protection. (See Exposure Controls, Personal Protection section). Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Avoid' generating dusty conditions. Remove all sources of ignition. Use a spark-proof tool. Do not let this chemical enter the environment. Section 7 - Handling and Storage Minimize dust generation and accumulation. Use spark-proof tools and explosion proof equipment. Do not get in Handling: eyes, on skin, or on clothing. Keep away fiom heat, sparks and flame. Do not ingest or inhale. Use only in a chemical fume hood. Keep away from sources of ignition. Store in a tightly closed container. Store in a dry area. Flammables-area. Storage: Keep refrigerated. (Store below 4OCI39"F.) Section 8 - Exposure Controls, Personal Protection I Chemical Name I ACGIH 1 NIOSH IOSHA - F i n a l PELS l I _ _ _ _ _ _ _ _ _ _ - - _ - - - - - _ - I - - _ - - - - - _ _ - - _ - _ - - - _ I - - - - - - _ _ - _ - _ _ - _ _ - - - I - _ - _ - _ - _ - _ - - _ - - _ - I I D i - t e r t - b u t y l d i c a r l n o n e l i s t e d lnone l i s t e d lnone l l s t e d I I bonate I I I I +-------------------- +------------------- +------------_------ +-----------------+ OSHA Vacated PELS: Di-tert-butyl dicarbonate: None listed Engineering Controls: Use explosion-proof ventilation equipment. Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use only under a chemical fume hood. Exposure Limits Personal Protective Equipment Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face Eyes: Skin: protection regulations in 29 CFR 19 10.133 or European Standard EN1 66. Wear appropriate protective gloves to prevent skin exposure. <<>> , clothing: Wear appropriate protective clothing to prevent skin exposure. Follow the OSHA respirator regulations found in 29 CFR 19 10.134 or European Standard E N 149. Use a Respirators: NIOSHIMSHA or European Standard E N 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - Physical and Chemical Properties Physical State: Physical State: Color: white Odor: characteristic odor pH: Not available Vapor Pressure: 1.33 hPa 6 70 deg C Vapor Density: Not available Evaporation Rate: Not available Viscosity: Not available Boiling Point: 37 deg C @ 0.5 mmHg ( 98.60°F) Freezingmelting Point: 22 - 24 deg C Decomposition Temperature: Not available Solubility in water: Hydrolysis. Specific GravitylDensity: 1.020 Molecular Formula: C 1 OH 1805 Molecular Weight: 2 1 8.25 Section I 0 - Stability and Reactivity Chemical Stability: Moisture sensitive. Incompatible materials, ignition sources: dust generation, excess heat, exposure to moist Conditions to Avoid: Incompatibilities with Other Materials Hazardous Decolnposition Products air or water. Reducing agents, acids, bases. Carbon monoxide, carbon dioxide, n-butanol, isobutylene. Hazardous Polymerization Will not occur Section 1 1 - Toxicological lnformation RTECS#: CAS# 24424-99-5: HT0230000 RTECS: LD50lLC50: CAS# 24424-99-5: Inhalation, rat: LC50 = I00 mdm314H; Other: One hour LC50 can be approximated as 400 mg11000 liter or .4 mglliter. Carcinogenicity: Di-tert-butyl dicarbonate - Not listed as a carcinogen by ACGTH, IARC, NTP, or CA Prop 65. Epidemiology: No information found Teratogenicity: No information found Reproductive: No information found Neurotoxicity: No information found Mutagenicity: No information found Other: See actual entry in RTECS for complete information. Section 12 - Ecological Information Other: Do not tinpty into drains. Section 13 - Disposal Considerations Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification. RCRA P-Series: None listed. RCRA U-Series: None listed. Section 14 - Transport lnformation <<>> , - uspor Shipping Name: TOXIC SOLIDS, FLAMMABLE, ORGANIC, N.O.S. Hazard Class: 6.1 UN Number: UN2930 Packing Group: 1 Canada TDG Shipping Name: TOXIC SOLIDS, FLAMMABLE, ORGANIC, N.O.S. Hazard Class: 6.1 UN Number: UN2930 Packing Group: I Section 15 - Regulatory Information US Federal TSC A CAS# 24424-99-5 is listed on the TSCA Inventory. Health & Safety List Chemical Test Rules Section 12b None of the chemicals are on the Health & Safety Reporting List. None of the chemicals in this product are under a Chemical Test Rule. None of the chemicals are listed under TSCA Section 12b. Significant New Use None of the chemicals in this material have a SNUR under TSCA. Rule CERCLA Hazardous Substances and corresponding RQs SARA Section 302 ' Extremely Hazardous Substances SARA Codes Section 3 13 None of the chemicals in this material have an RQ. Clean Air Act: None of the chemicals in this product have a TPQ. CAS # 24424-99-5: flammable, reactive. No chemicals are reportable under Section 3 13. This material does not contain any hazardous air pollutants. This material does not contain any Class 1 Ozone depletors. This material does not contain any Class 2 Ozone depletors. None of the chemicals in this product are listed as Hazardous Substances under the CWA. None of the chemicals in this product are listed as Priority Pollutants under the CWA. None of the chemicals in this product are listed as Toxic Pollutants under the CWA. Clean Water Act: OSHA: STATE California Prop 65 California No Significant Risk Level: Di-tert-butyl dicarbonate is not present on state lists from CA, PA, MN, MA, FL, or NJ. None of the chemicals in this product are listed. European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: T+ Risk Phrases: R 1 1 Highly flammable. R 26 Very toxic by inhalation. R 36/37/38 Irritating to eyes, respiratory system and skin. R 43 May cause sensitization by skin contact. Safety Phrases: S 7 Keep container tightly closed. S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. <<>> S 28 After contact with skin, wash immediately with ... S 33 Take precautionary measures against static discharges. S 36/37/39 Wear suitable protective clothing, gloves and eyelface protection. S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). WGK (Water DangerProtection) CAS# 24424-99-5: Not available Canada CAS# 24424-99-5 is listed on Canada's DSL List Canadian WHMIS Classifications: B4, D I A, D2B This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations and the MSDS contains all of tlie information required by those regulations. CAS# 24424-99-5 is not listed on Canada's Ingredient Disclosure List. Section 16 - Other l~iformation MSDS Creation Date: 1/14/1998 Revision #8 Date 1 1/26/2007 Revisions were made in Sections: 2, 3, 4, 5, 6,7, 8 , 9 , 10, 12 The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantibility or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigatidns to determine the suitability of the information for their particular purposes. In no event shall the company be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential, or exemplary damages howsoever arising, even if the company has been advised of the possibility of such damages. <<>> Page 1 / 7 Material Safety Data Sheet acc. to OSHA and ANSI P r i n t i n g d a t e 11/10/2008 1 Identification of substance: Product details: Product name: Di-tert-butyl dicarbonate Stock number: A1 4 708 LO3289 Reviewed on 10/01/2008 A l f a A e s a r , A Johnson M a t t h e y Company Johnson M a t t h e y C a t a l o g Company, I n c . 30 Bond S t r e e t Ward H i l l , MA 01835-8099 Emergency Phone: ( 9 7 8 ) 521 -6300 CHEMTREC: ( 8 0 0 ) 424 -9300 Web S i t e : www.alfa.com Information Department: H e a l t h , S a f e t y and Environmental Department Emergency informa tion: During normal h o u r s t h e H e a l t h , S a f e t y and Environmental Department. A f t e r normal h o u r s c a l l Chemtrec a t ( 8 0 0 ) 424-9300. 2 Composition/Data on components: Chemical characterization : Description : (CAS#) D i - t e r t - b u t y l d i c a r b o n a t e (CAS# 24424-99-5) : 100% Identification number(s) : EINECS Number: 246-240-1 3 Hazards identification Hazard description : T i V e r y t o x i c Information pertaining to particular dangers for man and environment R 26 V e r y t o x i c by i n h a l a t i o n . R 37/38 I r r i t a t i n g t o r e s p i r a t o r y s y s t e m and s k i n . R 4 1 R i s k o f s e r i o u s damage t o e y e s . R 4 3 M a y c a u s e s e n s i t i z a t i o n b y s k i n c o n t a c t . Classification system HMIS ratings (scale 0-4) (Hazardous Materials Identification System) riq REACTIVITY @ H e a l t h ( a c u t e e f f e c t s ) = 3 F l a m m a b i l i t y = 2 R e a c t i v i t y = 1 i 4 First aid measures General information I m m e d i a t e l y remove a n y c l o t h i n g s o i l e d b y the p r o d u c t . Remove b r e a t h i n g a p p a r a t u s o n l y a f t e r c o n t a m i n a t e d c o m p l e t e l y removed. I n c a s e o f i r r e g u l a r b r e a t h i n g o r r e s p i r a t o r y a r r e s t r e s p i r a t i o n . c l o t h i n g h a s b e e n p r o v i d e a r t i f i c i a l Icontd. on page 2) " USA - <<>> Page 2/7 Material S a f e t y Data Sheet acc. to OSHA and ANSI Printing date 11/10/2008 Reviewed on 10/01/2008 I Product name: Di - tert -butyl dicarbonate I - -. f c o n t d . o f page 1) After inhalation Supply fresh air. If required, provide art if icial respiration. Keep patient warm. Seek immedia te medical advice. After skin contact Immedia tel y wash wi th water and soap and rinse thorough1 y . Seek immedia te medical advice . After eye contact Rinse opened eye for several minutes under running water. Then consult a doctor. After swallowing Seek immediate medical advice. " " 5 Fire fighting measures Suitable extinguishing agents Use carbon dioxide, extinguishing powder or foam. Water may be ineffective but may be used for cooling exposed containers. Special hazards caused by the material, its products of combustion or resul ting gases : In case of fire, the following can be released: Carbon monoxide and carbon dioxide Protective equipment : Wear self -contained respirator. Wear fully protective impervious suit. 6 Accidental re1 ease measures Person-related safety precautions: Wear protective equipment. Keep unprotected persons away. Ensure adequate ventilation Measures for environmental protection: Do not allow material to be released to the environment without proper governmental permits. Measures for cleaning/collecting: Dispose contaminated material as waste according to item 13. Ensure adequate ventilation. Additional information: See Section 7 for information on safe handling See Section 8 for information on personal protection equipment. See Section 13 for disposal information. 7 Handling and storage Hand1 ing Infonnation for safe handling: Xandle under dry protective gas. Keep container tightly sealed. Ensure good ventilation at the workplace. Open and handle container with care. Only handle and refill product in closed systems. Infonnation about protection against explosions and fires : Keep ignition sources away. Storage Requirements to be met by storerooms and receptacles: Ref rigera t e ( C o n t d . on page 3 ) " " USA - <<>> Page 3 / 7 Material Safety Data Sheet acc. to OSHA and ANSI Printing date 11/10/2008 Reviewed on 10/01/2008 I Product name: Di- tert-butyl dicarbonate I (Contd. of page 21 Information about storage in one common storage facility: Store away from oxidizing agents. Protect from heat. Store away from water/moisture. Further in forma tion about storage conditions: Store under dry inert gas. This product i s moisture sensitive. Keep container t i g h t l y sealed. Protect from humidity and water. Refrigerate ... 8 Exposure controls and personal protection Additional information about design of technical systems: Properly operating chemical fume hood designed for hazardous chemicals and having an average face velocity o f a t least 100 feet per minute. Components with limit values that require monitoring at the workplace: Not required. Additional information: No data Personal protective equipment General protective and hygienic measures The usual precautionary measures for handling chemicals should be followed. Keep away from f o o d s t u f f s , beverages and feed. Remove a1 1 soiled and contaminated clothing immediately. Wash hands before breaks and at the end o f work. Store protective clothing separately. Avoid contact with the eyes and skin. Breathing equipment : Use suitable respirator when high concentrations are present. Protection of hands: Impervious gloves Check protective gloves prior t o each use for t h e i r proper condition. Material of gloves The selection o f suitable gloves not only depends on the material, but also on quality. Quality w i l l vary from manufacturer t o manufacturer. Eye protection: Safety glasses Body protection: Protective work clothing. 9 Physical and chemical properties: - - - - --- - - - . 1 General Informa tion I I..." .............. 1 Fonn : Low melting solid I White . . . . . . . . . . . , . . . . . .- - USA --.. <<>> Page 4/7 Material Safety Data Sheet acc. to OSHA and ANSI Printing date 11/10/2008 Reviewed on 10/01/2008 r-.-. ............... ........................................................................... ...................................... 1 Product name: Di-tert-butyl dicarbonate ..... --- .. - Decomposi tion temperature : Not determined I..... _ ' Danger of explosion: Product does not present an Lower : Not determined i Upper: Not determined I . .. . . Not determined -i Density at 20°C (68OF): 0.95 g/cm i Water : Slightly soluble 1 l o s t a b i l i t y and reactivity Thermal decomposition / conditions to be avoided: Decomposition will not occur if used and stored according to specifications. Ha terials to be avoided: Oxidizing agents Heat Wa t er/moi s t ure Dangerous reactions No dangerous reactions known Dangerous products of decomposition: Carbon monoxide and carbon dioxide 1 11 Toxicological information Acute toxicity: .. .......... - ....... ................................ ..... LD/LC5O values that are relevant for classification: 7 ................. ........................................................ -. ..... . Ora 1 ! LD50 25000 mg/kg (mam) I i 25000 mg/kg (rat) I ! Dermal i LD50 i 22000 mg/kg (mam) I i 22000 ~ng/kg (rabbit) I I Inhalative / LC50/4H 1 100 rng/m3/4H (rat) I - ...................................................................... i .......................... ................ .......................................................................................................... ........................ .- - ! Primary irritant effect : on the skin: Irritant to skin and mucous membranes. on the eye: Strong irritant with the danger of severe eye injury. Sensitization: Sensitization possible through skin contact. Subacute to chronic toxicity: I Extrnal MSDS reports that exposure to mist or aerosol may cause irreversible ocular opacity. Subacute to chronic toxicity: The Registry of Toxic Effects of Chemical Substances (RTECS) reports the following effects in laboratory animals: Sense Organs and Special Senses (Eye) - effect, not otherwise specified. Lungs, Thorax, or Respiration - dyspnea . Nutritional and Gross Metabolic - weight loss or decreased weight gain. (Contd. on page 5 ) L ..... .... - -. USA - <<>> Page 5 / 7 Material Safety Data Sheet acc. to OSHA and ANSI P r i n t i n g d a t e 11/10/2008 ' Prodvc t name : D i - t e r t -bu t y l dicarbona t e - . I . " ........................... ........ " ...... Reviewed on 10/01/2008 (Contd. of page 41 Additional t o x i c o l o g i c a l i n f o r m a t i o n : To t h e b e s t o f o u r knowledge t h e a c u t e and c h r o n i c t o x i c i t y o f t h i s s u b s t a n c e i s n o t f u l l y known. N o c l a s s i f i c a t i o n d a t a on c a r c i n o g e n i c p r o p e r t i e s o f t h i s m a t e r i a l a v a i l a b l e from t h e EPA, IARC, NTP, OSHA or ACGIH. i s ................................. 12 Ecological information: 1 General n o t e s : Do not a l l o w u n d i l u t e d p r o d u c t o r l a r g e q u a n t i t i e s o f it t o r e a c h ground w a t e r , w a t e r c o u r s e or sewage s y s t e m . Do not a l l o w m a t e r i a l t o b e r e l e a s e d t o t h e e n v i r o n m e n t w i t h o u t p r o p e r governmental p e r m i t s . - 13 Disposal considerations r Product : Recommenda ti on C o n s u l t s t a t e , l o c a l or n a t i o n a l r e g u l a t i o n s t o e n s u r e p r o p e r d i s p o s a l . Uncleaned packagings : Recommendation: . -. ...................... .......................... .- . ..... .A D i s p o s a l must be made a c c o r d i n g t o o f f i c i a l r e g u l a t i o n s . 14 Transport infoma tion 1 ' DOT r e g u l a t i o n s : 1 Hazard c l a s s : 6.1 1 I d e n t i f i c a t i o n n u m b e r : 1 P a c k i n g g r o u p : UN2811 11 / Proper s h i p p i n g name ( t e c h n i c a l i name): TOXIC SOLID, ORGANIC, N . 0. S . (Di - t e r t - 1 b u tyl d i carbona t e ) I Label 6.1 I .- ....................................... .. .................................. / Land t r a n s p o r t ADR/RID ( c r o s s - b o r d e r ) I I I i ADR/RID c l a s s : 6.1 (T2) T o x i c s u b s t a n c e s j Danger code (Kemler) : 6 0 I I 1 UEI-Number : 281 1 j Packaging group : 11 j - . , (Contd. on page 61 -\- USA - <<>> Page 6/7 Material Safety Data Sheet acc. to OSHA and ANSI Printing date 11/10/2008 Reviewed on 10/01/2008 I Product name: Di- tert-butyl dicarbonate I (Contd. o f page 5 ) 1 Description of goods: 2811 TOXIC SOL.rD, ORGANIC, N.O.S. (Di- I tert-butyl dicarbonste) I IMDG Class: 6.1 UN Number: 2811 Label 6.1 Packaging group: I1 Proper shipping name : TOXIC SOLID, ORGANIC, N. 0. S. (Di -tert- bu tyl di carbona t e) Air transport ICAO- TI and IATA-DGR : / ICAO/IATA class : i UN/ID Number: 1 Label I Packaging group: I I Proper shipping name : IC, N.O.S. (Di-tert- 15 Regulations Product related hazard informations: Hazard symbols : Tt Very toxic Risk phrases: 26 Very toxic by inhalation. 37/38 Irritating to respiratory system and skin 41 Risk of serious damage to eyes. 43 May cause sensitization by skin contact. Safety phrases : 2 6 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 28 After contact with skin, wash immediately with plenty of water 36/3 7/39 Wear suitable protective clothing, gloves and eye/face protection. 4 5 In case of accident or if you feel unwell, seek medical advice immediately. National regulations All components of this product are listed in the U. S. Environmental Protection Agency Toxic Substances Control Act Chemical substance Inventory. All components of this product are listed on the Canadian Domestic Substances List (DSL) . (Contd. on page 7 ) - USA - <<>> Page 7 / 7 Material Safety Data Sheet acc. to OSHA and A N S I Printing date 11/10/2008 I Product name: D i - t e r t - b u t y l dicarbonate Reviewed on 10/01/2008 (Contd. of page 61 Information about l i m i t a t i o n o f u s e : For use only by technically qua1 i f ied individuals. 16 Other information: Employers should use t h i s information only as a supplement t o other information gathered by them, and should make independent judgement o f s u i t a b i l i t y o f t h i s information t o ensure proper use and protect the health and s a f e t y o f employees. This information i s furnished without -warranty, and any use o f the product not i n conformance with t h i s Material Safety Data Sheet, or i n combination with any other product or process, i s the responsibility o f the user. Department i s s u i n g MSDS: Health, Safety and Environmental Department. Contact: Paul V . Connolly " ...-...-----p-- USA A <<>> S A F E T Y D A T A S H E E T 1. IDENTIFICATION OF THE SUBSTANCEIPREPARATION AND COMPANYIUMDERTAKING Synonyms Dlboc Chemical chafacterlzatfon Solid. Llquld. Product code 1001021,101 1664,3515019 Supplier SIber Hegner Raw Materials LTD. P.0.Box 688 CH-8034 ZOrich Switzerland 01 386 73 46 Emergency telephone number t*41 1 386 73 46 2. COMPOSITIONIINFORMATION ON INGREDIENTS - Hazardous components CAS No., : 24424-99-5 EINECS NO. : 256-240-1 3. HAZARDS IDENTIFICATION Irritating to eyes and skin. May cause 8 contaot. Flammable. Hannful In contact swallowed. Very toxic by inhaletlon. 4. FIRST AID MEASURES inhalation Skin contact Eye contact Move to fresh air. Oxygen or artlftclal re! Consult a physician for severe cases. Wash off lmmedlately wilh soap and ple Rlnse lmmedlately with plenty of water, eyelids, for at least 15 minutes. If eye in consult a specialist Ingestion Rinse mouth. <<>> 1 9 . ; 6. FIRE-FIGHTING MEASURES * Suitable extinguishing media Carbon dloxlde (C02). Foam. Dry powder. Speclal protective equipment for firefighters Wear proteotive sult. Wear self contained breathing apparatus for fire fighting If necessary. 6. ACCIDENTAL RELEASE MEASURES Personal precautions Environmental precautions Methods for cleaning up Do not breathe gaslfumealvapourlspray. Do not flush into surface water or sanitary sewer system. Sweep up and shovel. Soak up wlth Inert absorbent material (e.g. sand, silica gel, acld binder, universal binder, sawdust). 7. HANDLING AND STORA(3E - .. Handling - Avold contact with dkin and eyes. Keep away from sources of Ignition - No smoking. Storage Keep containers tlghtly closed In a dry, cool and wel - **truncated:** true - **body characters:** 52082