# Patterson Companies, Inc — Hazardous Materials Safety Interpretation - **operation:** document - **citation:** 14-0008 - **title:** Patterson Companies, Inc — Hazardous Materials Safety Interpretation - **source type:** guidance - **agency:** Pipeline and Hazardous Materials Safety Administration - **status:** guidance - **official:** true - **published on:** 2014-07-29 - **effective on:** Not available - **summary:** 14-0008 response to Patterson Companies, Inc concerning 173.132, 173.133. - **machine formats:** - **json:** https://regulus.evalyn.ai/document/phmsa-interpretation-14-0008.json - **markdown:** https://regulus.evalyn.ai/document/phmsa-interpretation-14-0008.md - **app url:** https://regulus.evalyn.ai/document/phmsa-interpretation-14-0008 - **source url:** https://www.phmsa.dot.gov/sites/phmsa.dot.gov/files/legacy/interpretations/Interpretation%20Files/2014/140008.pdf **body:** <<>> U.S. Department 1200 New Jersey Avenue, SE of Transportation Washington, D.C. 20590 Pipeline and Hazardous Administration Materials Safety JUL 2 9 2014 Robb Boros Regulatory Compliance Specialist Patterson Companies, Inc. 1905 Lakewood Drive Boone, Iowa 50036 Ref. No.: 14-0008 Dear Mr. Boros: This responds to your January 10, 2014 letter requesting clarification of the term maximum attainable concentration concerning inhalation toxicity for Division 6.1 poisonous materials under the Hazardous Materials Regulations (HMR; 49 CFR Parts 171-180). According to the information in your letter and the material safety data sheet (MSDS) you provided, you have identified your material as Halamid® with chemical names of Benzene sulfonamide, N-Chloro-4-methyl, or sodium salt; synonyms of Sodium p- Toluenesulfonchloramide or Chloramine-T; and C.A.S. Registry Numbers of 127-65-1 (anhydrous) / 7080-50-4 (trihydrate)'. Further, the MSDS classified the material as "UN3263, Corrosive solid, basic, organic, n.o.s. (Sodium p-toluenesulfonchloramide), 8, PG III." Also, the acute toxicity test data values provided in the MSDS and used in the classification are as follows: Inhalation toxicity by dusts and mists LC50 (mg/L): Acute exposure: The acute 4 hr. LCso for this product in rats is greater than 0.275 mg/L (maximum attainable dust concentration). Dermal toxicity LD50 (mg/kg): Acute contact: Dermal toxicity (LDso) is greater than 2,000 mg/kg in rabbits (8% solution). The pure powder form of Halamid® is corrosive to rabbit skin following a 4 hour exposure period while an 8% solution is not irritating to skin. Oral toxicity LD50 (mg/kg): Acute exposure: The oral LDso for this material is approximately 1,000 mg/kg (rat/mice). ' Provided in the MSDS, the anhydrous substance (CAS# 127-65-1) covers all hydrated forms of this product. The trihydrate substance (CAS# 7080-50-4) is the only commercially available and chemically stable form of Sodium p-Toluenesulfonchloramide. <<>> Finally, in your letter you provide a link to an Organization for Economic Cooperation and Development (OECD) document entitled "OECD Guideline for the Testing of Chemicals? which discusses guidelines for testing of acute inhalation toxicity materials. Your questions are paraphrased and answered below. Q1: You ask what the term "maximum attainable concentration" means in paragraph 30, page 7, of the Revised OECD Guideline 403 (Acute Inhalation Toxicity): Al: As provided in the OECD guideline, the protocol for the limit test states: A limit test is used when the test article is known or expected to be virtually non-toxic, i.e., eliciting a toxic response only above the regulatory limit concentration. In a limit test, a single group of three males and three females is exposed to the test article at a limit concentration. Information about the toxicity of the test material can be gained from knowledge about similar tested compounds or similar tested mixtures or products, taking into consideration the identity and percentage of components known to be of toxicological significance. In those situations where there is little or no information about its toxicity, or the test material is expected to be toxic, the main test should be performed The selection of limit concentrations usually depends on regulatory requirements. When the GHS Classification System is used, the limit concentrations for gases, vapours, and aerosols are 20,000 ppm, 20 mg/L, and 5 mg/L, respectively (or the maximum attainable concentration). It can be technically challenging to generate limit concentrations of some test articles, especially as vapours and aerosols. When testing aerosols, the primary goal should be to achieve a respirable particle size (MMAD of 1-4 jim). This is possible with most test articles at a concentration of 2 mg/L. Aerosol testing at greater than 2 mg/L should only be attempted if a respirable particle size can be achieved (see GD 39). GHS discourages testing in excess of a limit concentration for animal welfare reasons (3). The limit concentration should only be exceeded when there is a compelling reason, such as a direct relevance to the protection of human health, and the reason must be explained in the study report. In the case of potentially explosive test articles, care should be taken to avoid conditions favourable for an explosion. To avoid an unnecessary use of animals, a test run should be conducted prior to the limit test to ensure that the chamber conditions for a limit test can be achieved. If mortality or moribundity is observed at the limit concentration, the results of the limit test can serve as a sighting study for further testing at other concentrations (see main study). If a test article's physical or chemical properties make it impossible to attain a limit concentration, the maximum attainable concentration should be tested. If less than 50% lethality occurs at the maximum attainable concentration, no further testing is necessary. The study report should contain an explanation and supportive ^ Organization for Economic Co-operation and Development (OECD) Guideline for the Testing of Chemicals, http://www.eecd.org/chemicalsafety/testing/41761261.pdf Draft Proposal for a Revised Guideline 403, Acute Inhalation Toxicity, 2 <<>> data for why the limit concentration could not be attained. If the maximum attainable concentration of a vapour does not elicit toxicity, it may be necessary to generate the test article as a liquid aerosol. The "maximum attainable concentration" is the greatest amount of test material that can be suspended and maintained in the air in an inhalation chamber to test for acute inhalation toxicity in conformance with the methods prescribed in OECD Guideline 403. Q2: You seek clarification on the MSDS's usage of "maximum attainable dust concentration" for the LCso inhalation toxicity, and whether the material meets a Division 6.1 definition and assignment of packing group as prescribed in §§ 173.132 and 173.133. A2: Under § 173.22 of the HMR it is a shipper's responsibility to properly classify a hazardous material. This Office does not generally perform that function. However, based on the test results provided in the MSDS, it is the opinion of this Office that the material does not meet the LCso criteria for acute inhalation toxicity. The HMR defines a poisonous material in § 173.132 as a material, other than a gas, that is known to be toxic to humans because it falls within one of the following categories when tested on laboratory animals: oral toxicity, dermal toxicity, and inhalation toxicity. Included in the definition under § 173.132(a)(1)(iii) for inhalation toxicity, if a dust or mist has an LCso of not more than 4 mg/L then it meets the Division 6.1 criteria. If the MSDS for Halamid® you provided is accurate and the "maximum attainable concentration" of 0.275 mg/L is not toxic, it is the opinion of this Office that this material would not meet the definition of a Division 6.1 material in addition to any other hazard class the material might meet. As such, the description "UN3263, Corrosive solid, basic, organic, n.o.s. (Sodium p-toluenesulfonchloramide), 8, PG III" is appropriate. I trust this satisfies your inquiry. Please contact us if we can be of further assistance. Sincerely, Ann taster T. Glenn Foster Chief, Regulatory Review and Reinvention Branch Standards and Rulemaking Division 3 <<>> Nickels $172.101 Drakeford, Carolyn (PHMSA) $ 173.226 Sent: From: Nickels, Matthew (PHMSA) 3173.221 To: Friday, January 10, 2014 11:38 AM Cc: Drakeford, Carolyn (PHMSA) Applicability Subject: Foster, Glenn (PHMSA) Attachments: FW: New Interp Request 14-0008 Halamid_Chloramine_T_MSDS_2005-0218.pdf Importance: High Hey Carolyn, as soon as you get a chance, please take this submitted e-mail as a new formal letter of interpretation request; and assign it to me. Thanks, Matt From: robb.boros@pattersoncompanies.com [mailto:robb.boros@pattersoncompanies.com] Sent: Friday, January 10, 2014 10:39 AM To: Nickels, Matthew (PHMSA) Subject: New Interp Request http://www.oecd.org/chemicalsafety/testing/41761261.pdf Check out page 7, item 30. I am looking to get clarification regarding "maximum attainable concentration" with regards to inhalation toxicity. If a chemical has a maximum attainable concentration less than or equal to 4.0mg/L, and death does not occur in at least to inhalation toxicity or is the chemical considered not toxic by inhalation? 50% of the population of rats at that concentration, does there need to be any further considerations made regarding solely For example, we distribute a product that is comprised of 90-100% Chloramine-T. The toxicity data indicates the product has an inhalation value (LC50 - rat) identified as being greater that 0.275 mg/L for a 4-hour exposure, and specifies this is the maximum attainable concentration. I have been unable to find any reference in the HMR regarding maximum attainable concentrations, nor have I found any guidance in existing interpretations. Thanks Robb Boros Patterson Companies, Inc. Regulatory Compliance Specialist 515.433.1700 (Fax 1701) otherwise exempt from disclosure under applicable law and is intended solely for the use of the individual(s) to whom it was NOTICE: This email transmission and any attachments that accompany it may contain information that is confidential or dissemination, distribution, copying or other use or retention of this communication or its substance is prohibited. If you intended to be addressed. If you have received this email by mistake, or you are not the intended recipient, any disclosure, have received this communication in error, please immediately report to the author via email that you received this message by mistake and also permanently destroy printed copies and delete the original and all copies of this email and any attachments from your computer. 1 <<>> axcentive Material Safety Data Sheet HALAMID® SECTION 1. CHEMICAL PRODUCT AND COMPANY INFORMATION Product Name: HALAMID ® Chemical Name: Benzene sulfonamide, N-Chloro-4-methyl, sodium salt Synonyms: Sodium p-Toluenesulfonchloramide ; Chloramine-T C.A.S. Registry No.: 127-65-1 (anhydrous) / 7080-50-4 (trihydrate) [See additional information in Sections 3 and 15] Chemical Formula: Cy Hy Cl N NaO_S (and hydrates) Product Use: Oxidizing agent Axcentive SARL Manufacturer / Supplier Chemin de Champouse 13320 Bouc Bel Air, France Tel. (33) 442 694 090 Emergency Telephone Number: (011) 31 570 679211 (Akzo Nobel Chemicals, Deventer, The Netherlands) Date of First Issue: September 24, 2004 Revision No.: 2.0 Revision Date: February 18, 2005 Changes: Sections 1, 2, 4, 11, 15 SECTION 2. HAZARDS INFORMATION EMERGENCY OVERVIEW This material is considered hazardous by the OSHA Hazard Communication Standard (29 CFR 1910.1200). DANGER! Causes skin and eye burns. May cause sensitization by inhalation and skin contact. May cause respiratory tract irritation. • • • Avoid contact with eyes, skin and clothing. Contact with acids liberates toxic gas. Wear appropriate personal protective equipment (see section 8 for additional information). Fire and Explosion Hazards: Potential for dust explosion may exist. This product is not defined as to loose water of crystallization at 122°F (60°C). Depending upon conditions, dust may be sensitive to static flammable or combustible but may decompose violently if heated above 266°F (130°C). This product will begin discharge. Avoid possibility of dry powder with friction causing static electricity in presence of flammables. (See NFPA-77, Chapter 6). Appearance and odor: White crystalline powder with a weak chlorine odor. POTENTIAL HEALTH EFFECTS [See Section 11 for additional information] Primary Route(s) of Exposure: Skin contact, eye contact and inhalation. However, years of use of Chloramine-T indicates that the risk of allergic skin reaction is limited. Skin Contact: Considered corrosive to the skin. Contact may cause allergic reaction in sensitive individuals. Eye Contact: Considered corrosive to the eyes. Inhalation: Inhalation of dust is irritating to mucous membranes and may cause asthma-like symptoms. Issue date: 18-Feb-05 MSDS No.: 04 - 041030 Expiry date: 18-Feb-08 Page 1/8 <<>> axcentive Material Safety Data Sheet HALAMID® SECTION 2. HAZARDS IDENTIFICATION (CONTINUED) Ingestion: Ingestion may cause irritation or burns of the mouth, throat, esophagus and stomach. Ingestion may cause nausea and vomiting Carcinogenicity: IARC, NTP, ACGIH or OSHA does not classify this material or its components as a carcinogen or suspect carcinogen. Medical conditions aggravated: Persons with pre-existing skin and/or respiratory disease may be at increased risk if exposed to this material. This product is not expected to be harmful to aquatic life, based on available data. POTENTIAL ENVIRONMENTAL EFFECTS [See Section 12 for additional information] SECTION 3. COMPOSITION / INFORMATION ON INGREDIENTS INGREDIENTS [See section 8 for exposure limits] % (w/w) CAS Number Benzene sulfonamide, N-Chloro-4-methyl, sodium salt 99.0-100.0 127-65-1/7080-50-41 The anhydrous substance (CAS# 127-65-1) covers all hydrated forms of this product. The trihydrate substance (CAS# 7080-50-4) is the only commercially available and chemically stable form of Sodium p-Toluenesulfonchloramide. SECTION 4. FIRST AID MEASURES water for at least 15 minutes. Do not attempt to neutralize with chemical agents. Get medical attention. Wash Skin Contact: Immediately remove contaminated clothing and shoes. Wash skin with soap and plenty of contaminated clothing before reuse. Thoroughly clean or destroy contaminated shoes. Eye Contact: Flush eyes with large quantities of running water for a minimum of 15 minutes. If the victim is surface of the eye and lids with water. DO NOT let victim rub eye(s). Do not attempt to neutralize with chemical wearing contact lenses, remove them. Hold the eyelids apart during the flushing to ensure rinsing of the entire agents. Oils or ointments should not be used at this time. Get medical attention if eye irritation occurs. Inhalation: Remove victim to fresh air. If respiratory irritation occurs or if breathing is difficult, get medical attention. If breathing has stopped, give artificial respiration. Maintain airway and administer oxygen if available. Get medical attention immediately. Ingestion: DO NOT induce vomiting. If victim is conscious and alert, rinse mouth and give plenty of water to drink. If vomiting occurs, keep head below hips to reduce risk of aspiration. Give fluids again. Activated charcoal may be administered (not during vomiting) preferably by a physician [See Note to Physician below]. Never give anything by mouth to a person who is unconscious or convulsing. If victim is unconscious, monitor pulse, breathing and airway. If breathing stops, begin artificial respiration immediately. If the heart has stopped, give cardiopulmonary resuscitation (CPR). Get medical attention immediately. charcoal slurry, suspend 50 g of activated charcoal in 400 ml of water in a plastic bottle and shake well. Note to Physician: Attending physician should treat exposed patients symptomatically. To prepare activated Administer 5 mi/kg or 350 mL for an average adult. [A literature reference suggests that Chloramine-T can react with some amino acids in the gastrointestinal tract to form cyanogen compounds]. Issue date: 18-Feb-05 MSDS No.: 04 - 041030 Expiry date: 18-Feb-08 Page 2/8 <<>> axcentive Material Safety Data Sheet HALAMID® SECTION 5. FIRE FIGHTING MEASURES Conditions of Flammability: Flash Point (Method): not flammable or combustible Upper Flammable Limit (% by volume): 377.6°F (192°C) [Pensky-Martens Closed Cup] Auto-Ignition Temperature: Lower Flammable Limit (% by volume): not applicable product decomposes prior to ignition not applicable Extinguishing Media: Use water fog or spray, dry chemical, foam or carbon dioxide extinguishing agents. Fire Fighting Procedures: As in any fire, prevent human exposure to fire, smoke, fumes or products of contained breathing apparatus and impervious protective clothing. If not leaking, keep fire-exposed containers combustion. Evacuate all non-essential personnel from the fire area. Fire fighters should wear full-face, self- cool with a water spray to prevent rupture due to excessive heat. Fire & Explosion Hazards: Potential for dust explosion may exist. This product is not defined as flammable or combustible. May decompose violently if heated above 266°F (130°C). This product will begin to loose water of crystallization at 122°F (60°C). Depending upon conditions, dust may be sensitive to static discharge. Avoid possibility of dry powder with friction causing static electricity in presence of flammables. (See NFPA-77, Chapter 6) distillation of the total water content. Other Fire & Explosion Hazards: This product has been reported as being explosive after azeotropic Hazardous Combustion Products: Thermal decomposition products may release toxic and/or hazardous fumes and gases, including sulfur oxides (SOx), nitrogen oxides (NOx), hydrochloric acid (HCI) and chlorine. NPFA 704 Hazard Rating - Health: 3 Fire: 1 Instability: 1 Other: None [0 - Minimal 1 - Slight 2 - Moderate 3 - High 4 - Extreme] SECTION 6. AccIDenTAL RELEASE MEAsureS Spill or Leak: Safely stop source of spill. Restrict non-essential personnel from area. All personnel involved in spill cleanup should avoid skin and eye contact by wearing appropriate personal protective equipment. Do not breathe dust. Cleanup: Sweep up spilled solid material, being careful not to create dust. Return sweepings to stock or, if regulations. Flush remainder with water. Do not allow to escape into sewage system or water courses. contaminated, place into a chemical waste container for disposal. Dispose of waste according to all SECTION 7. HANDLING AND STORAGE Handling: Avoid inhalation of dust and prolonged and/or repeated skin and eye contact. cool, dry, well-ventilated area away from flammable, reducing or oxidizing materials and sources of heat or Storage: Store away from foodstuffs or animal feed. Containers should be kept tightly capped and stored in a flame. Exercise due caution to prevent damage to or leakage from the container. Maximum Storage Temperature: 140°F (60°C) - Storage at higher temperatures will cause loss of crystalline structure. General Comments: Avoid generation of dust when handling this product. Follow good manufacturing and handling practices. Issue date: 18-Feb-05 Expiry date: 18-Feb-08 MSDS No.: 04 - 041030 Page 3/8 <<>> axcentive Material Safety Data Sheet HALAMID® SECTION 8. ExposurE CoNTrOL / PERSONAL PROTECTION Applicable Exposure Limits: In addition to any exposure limits displayed below, exposures to this product • OSHA - 15 mg/m (total dust) ; 5 mg/m (respirable fraction) should be controlled below limits established for "Particulates Not Otherwise Classified (PNOC)": OSHA - PELS Chemical Name (mg / m) ACGIH - TLVs NIOSH - RELS (mg / m3) (mg / m°) TWA STEL / CEIL(C) TWA STEL / CEIL(C) TWA STEL I CEIL(C) SUPPLIER sulfonchloramide Sodium p-Toluene N/D N/D N/D N/D N/D N/D N/D [Ref: ACGIH Guide to Occupational Exposure Values, 2004 Edition] Legend: STEL: Short Term Exposure Limit CEIL: Ceiling Exposure Limit TLV: Threshold Limit Value PEL: Permissible Exposure Limit RE Tinene Average Limit. N/D: Not Determined Engineering Control - Ventilation: Special ventilation is usually not required under normal use conditions. Ensure that existing ventilation is sufficient to prevent the circulation and/or accumulation of dust in the air. Personal Protective Equipment (PPE) respirator with acid gas, dust, mist and fume filters. When using respirator cartridges or canisters, they must be Respiratory Protection: If handling operations lead to dusting, wear a NIOSH-approved air-purifying full-face not occur. changed frequently (following each use or at the end of the work shift) to assure breakthrough exposure does Skin Protection: Skin contact with the product should be minimized through the use of suitable protective clothing, gloves and footwear selected with regard for use condition exposure potential. Eye Protection: Indirect vented, dust-tight goggles are recommended if dust is generated when handling this product. Eye wash facility should be readily available. separate area away from the storage/use location. Eating, drinking and smoking should be prohibited in areas Other Protection - General Hygiene Considerations: All food and smoking materials should be kept in a where there is a potential for significant exposure to this material. Before eating, drinking and smoking, hands and face should be thoroughly washed. Safety showers, with quick opening valves, which stay open, and eyewash fountains, or other means of washing the eyes with a gentle flow of cool to tepid tap water, should be readily available in all areas where this material is handled or stored. Water should be supplied through insulated and heat-traced lines to prevent freeze-up in cold weather. Long sleeved clothing may be used to minimize skin contact. SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES Boiling Point: Physical State / Appearance / Odor: not determined white crystalline powder with a weak chlorine odor Bulk Density: ~ 590 kg/m° Cloud Point: not determined Evaporation Rate (Butyl Acetate=1): not determined Odor Threshold: Melting Point: not determined not determined (decomposes before melting) pH: Pour Point: Partition Coefficient [Octanol-Water] log Kow = - 1.3 8 - 10.3 (5% solution) Solubility in water: not determined Solubility in other solvents: 150 g/l @ 25°C 75 g/1 @ 20°C in 95% ethanol Issue date: 18-Feb-05 MSDS No.: 04 - 041030 Expiry date: 18-Feb-08 Page 4/8 <<>> axcentive Material Safety Data Sheet HALAMID® SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES (CONTINUED) Specific Gravity (HO = 1): Vapor Density (Air = 1): 1430 kg/m Vapor Pressure: not applicable Viscosity: not determined Volatiles (% by weight): not applicable not determined Conditions of Flammability: not flammable or combustible Flash Point (Method): Upper Flammable Limit (% by volume): not applicable 377.6°F (192°C) [Pensky-Martens Closed Cup] Auto-Ignition Temperature: Lower Flammable Limit (% by volume): not applicable product decomposes prior to ignition <: less than > : greater than ~: approximately SECTION 10. STABILITY AND REACTIVITY Stability: This product is stable under recommended storage and handling conditions (see section 7) However, it may decompose if exposed to elevated temperatures. It will become unstable in humid conditions. oxidizers. Contact with acids liberates toxic gas. Avoid prolonged storage at elevated temperatures. Incompatibilities / Conditions to avoid: This product is incompatible with acids, reducing agents and strong Polymerization: Hazardous polymerization is not expected to occur under normal temperatures and pressures. Hazardous Combustion Products: Thermal decomposition products may release toxic and/or hazardous fumes and gases, including sulfur oxides (SOx), nitrogen oxides (NOx), hydrochloric acid (HCI) and chlorine. SECTION 11. TOXICOLOGICAL INFORMATION INHALATION Acute exposure: The acute 4 hr. LC50 for this product in rats is greater than 0.275 mg/L (maximum Chronic exposure: This product may cause asthma-like symptoms based on limited human data. attainable dust concentration). SKIN form of Halamid is corrosive to rabbit skin following a 4 hour exposure period while an 8% solution is not Acute contact: Dermal toxicity (LD50) is greater than 2,000 mg/kg in rabbits (8% solution). The pure powder irritating to skin. Chronic contact: No data available. EYES: This product is corrosive to rabbit eyes. INGESTION Acute exposure: The oral LD50 for this material is approximately 1,000 mg/kg (rat/mice). Chronic exposure: In a 90 day feeding study, the NOEL (No Observed Effect Level) in albino rats was approximately 15 mg/kg. SENSITIZATION: This product was a strong skin sensitizer in the guinea pig maximization test and local lymph node assay. However, years of use of Chloramine-T indicates that the risk of allergic skin reaction is Issue date: 18-Feb-05 MSDS No.: 04 - 041030 Expiry date: 18-Feb-08 Page 5/8 <<>> axcentive Material Safety Data Sheet HALAMID® SECTION 11. TOXICOLOGICAL INFORMATION (CONTINUED) CARCINOGENICITY: IARC, NTP, ACGIH or OSHA does not classify this material or its components as a carcinogen or suspect carcinogen. MUTAGENICITY: This product gave negative results in the Ames test, mouse lymphoma forward mutation assay, DNA repair test, and in vivo mouse micronucleus assay at doses up to 1200 mg/kg. REPRODUCTIVE TOXICITY / TERATOGENICITY / NEUROTOXICITY: No data are currently available. OTHER TOXICOLOGICAL EFFECTS: None known TARGET ORGANS: Skin, eyes and respiratory system. SECTION 12. ECOLOGICAL INFORMATION Ecotoxicity: This product is not expected to be harmful to aquatic life, based on the following ecotoxicity data: Test Fathead Minnow Guppies (Poecilia Reticulata) Exposure / Duration 96-h LC50 = 31 mg/L Test Results Saltwater Brine Shrimp 35 days 72-h NOEC = 1.1 mg/L (early life stage study) EC50 = 24.6 mg/L ; NOEC = 10.4 mg/L Daphnia magna 21 days (chronic 48-h EC50=> 23 mg/L (flow through conditions) LC50 = 4.5 mg/L (static conditions) study). EsC5o (reduction in growth) = 4.5 mg/L NOEC = 1.1 mg/L ; LOEC = 3.5 mg/L Inhibition Freshwater Algal Growth 96-h E,C50 (reduction in specific growth rate) = 13 mg/L NOEC = 0.2 mg/L LOEC = 0.6 mg/L Algae (Chlorella pyrenoidosa) 96-h EC50 = 5 mg/L (Aerobic saprophytic bacteria) EC50 = 80 mg/L, as PTSA (para-Toluenesulfonamide) Activated Sludge Bacteria None specified EC50 = 1000 mg/L (Methanogenic bacteria) EC5o = 700 mg/L (Nitrifying bacteria) Pseudomonas Putida Bacteria Earthworms (Eisenia fetida) 7 days None specified EC10 = 10 ppm (mg/L) .C50 = 527 mg/kg speedy biodegradability indicate a low bioaccumulation potential. Bioaccumulation: The high solubility in water of this product, its low adsorption to soil and sludge and its Chemical Fate / Biodegradation: This product is readily biodegradable if it is in sufficiently low toluene sulfonamide that biodegraded 90% in 28 days in the Repetitive Die Away Test. concentrations in water. The hydrolysis product is also readily biodegradable. This product hydrolyses to p- SECTION 13. DISPOSAL CONSIDERATIONS waste by characteristics or listings. It is the responsibility of the waste generator to evaluate whether his Waste Disposal: in its unused condition, this product is not considered to be a RCRA defined hazardous wastes are hazardous by characteristic or listing. Dispose in accordance with all local, state and federal regulations emptied containers retain product residue, follow label warnings even after container is emptied. Empty Container Disposal: Containers should be cleaned of residual product before disposal or return. Since containers should be disposed of or shipped in accordance with all applicable laws and regulations. Issue date: 18-Feb-05 MSDS No.: 04 - 041030 Expiry date: 18-Feb-08 Page 6/8 <<>> axcentive Material Safety Data Sheet HALAMID® SECTION 14. TRANSPORT INFORMATION IMDG, ICAO/IATA] as follows: Shipping Information: This product is regulated for shipping by all modes [per US DOT, Canada TDG, Corrosive solid, basic, organic, n.o.s. [Sodium p-toluenesulfonchloramide] 2004 Emergency Response Guidebook No.: 154 8, UN3263, PG III Required Labels: Corrosive Environmentally Hazardous Substance [per 49 CFR 172.101, Appendix A or B): None SECTION 15. REGULATORY INFORMATION The component is subject to the following environmental regulatory lists: Substance Name CAA CERCLA IARC US STATE RIGHT: TO-KNOW LISTS PROP 65 SARA Sodium p-Toluene sulfonchloramide N/R N/R N/R N/R N/R N/R National Chemical Inventories Status: Substance Name TSCA US DSL Canada NDSL EINECS EU Australia® AICS Japan ENCS Korea KECL Philippines PICCS China sulfonchloramide Sodium p-Toluene- (see note below) x x x x x x N/R = Non Regulated X= Listed Other Regulatory Information: For inventory reporting purposes, listing of the anhydrous substance [CAS# 127-65-1] covers all hydrated forms of this product. The trihydrate substance (CAS# 7080-50-4) is the only commercially available and chemically stable form of Sodium p-Toluenesulfonchloramide. AICS Legend CA List Australian Inventory of Chemical Substances CERCLA CAA Clean Air Act, Section 112 California - Directors List of Hazardous Substances EINECS DSL Domestic Substances List - Canada FL List ENCS European Inventory of Existing Commercial Chemical Substances Japan Existing and New Chemical Substances KECL IARC International Agency for Research on Cancer - Carcinogens - Groups 1, 2A or 2B MN List MA List Massachusetts - R-T-K Substance List Korea Existing and Evaluated Chemical Substances NJ R-T-K NDSL Minnesota - Hazardous Substance List Non-Domestic Substances List - Canada PA List New Jersey - R-T-K Hazard List Prop 65 PICCS Pennsylvania Hazardous Substance List Philippines Inventory of Chemicals and Chemical Substances SARA RI List Rhode Island - Hazardous Substance List TSCA Toxic Substances Control Act - USA SARA Title III, Section 302 / 313 WHMIS (Workplace Hazardous Materials Information System - Canada) • Class D2A, D2B [Other toxic effects] Class E [Corrosive] the MSDS contains all the information required by the CPR. This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations (CPR) and [0 - Minimal HMIS Rating - Health: 3 1 - Slight Flammability: 1 2 - Moderate 3 - High Reactivity: 1 4 - Extreme *- Chronic Health Hazard (see Section 11)] Other: none Issue date: 18-Feb-05 MSDS No.: 04-041030 Expiry date: 18-Feb-08 Page 718 <<>> axcentive Material Safety Data Sheet HALAMID® SECTION 16. OTHER INFORMATION Other Information: None available. Prepared by: ANCI Regulatory Toxicology Dept. [M. Morin - Tel. (613) 273-8095] formation concerning this product and/or all suggestions for handling and use contained herein are offered in good faith and are believed to be reliable as of th le information in this Material Safety Data Sheet should be provided to all who will use, handle, store, transport or otherwise be exposed to this product All date of publication. including mixing with other products. or extending any license under any patent. document is more than three years old, please call to ensure that this sheet is current. sue date: 18-Feb-l niry date: 18-Feh-( MSDS No.: 04 - 041030 Page 8/8 - **truncated:** false - **body characters:** 30693