{"operation":"document","citation":"98-0240","title":"Musashino Chemical Laboratory, — Hazardous Materials Safety Interpretation","source_type":"guidance","agency":"Pipeline and Hazardous Materials Safety Administration","status":"guidance","official":true,"published_on":"1998-10-23","effective_on":null,"summary":"98-0240 response to Musashino Chemical Laboratory, concerning 172.101.","machine_formats":{"json":"https://regulus.evalyn.ai/document/phmsa-interpretation-98-0240.json","markdown":"https://regulus.evalyn.ai/document/phmsa-interpretation-98-0240.md"},"app_url":"https://regulus.evalyn.ai/document/phmsa-interpretation-98-0240","source_url":"https://www.phmsa.dot.gov/sites/phmsa.dot.gov/files/legacy/interpretations/Interpretation%20Files/1998/980240.pdf","body":"<<<PAGE 1>>>\n\nU.S. Department\nof Transportation\nResearch and\nSpecial Programs\nOCT 23 1998\nAdministration\nMr. Yukawa Muneaki\nTechnical Department Manager\nRef. No.\n98-0240\nMusashino Chemical Laboratory, Itd.\nYaesu-Daibiru Bldg.\n1-1, Kyobashi I-Chome, Chuo-Ku\nTokyo 104 Japan 0031\nDeax Mr. Muneaki:\nThis is in response to your letter dated August 18, 1998,\nregarding the applicability of the Hazardous Materials\nRegulations (HMR; 49 CFR Parts 171-180) to lactic acid and its\nderivatives.\nmaterial as defined in the HMR.\nSpecifically, you ask if lactic acid is a class 8\nunderstanding that lactic acid is\nYou also state that it is your\ndermal irritation/corrosion classification contained in the 1992\na class 8 material based on the\nGuideline for Testing of Chemicals.\nOrganization for Economic Cooperation and Development (OECD)\nUnder § 173.136 of the HMR, class 8 materials are liquids or\nsolids that cause full and irreversible thickness destruction of\nhuman skin at the site of contact within a specified period of\nA liquid that has\na severe corrosion rate on steel or\naluminum based on the criteria in § 173.137 (c) (2) is also a\ncorrosive material.\nafter\nA packing group is\nevaluating data obtained from testing conducted in\nassigned to the material\naccordance with OECD Guidelines, and then determined from the\ncriteria specified in § 173.137.\nIf your material has been tested for skin corrosion using a\npreviously authorized test method\nthere is no need to retest it.\nIf you choose to have your\nand found to be not corrosive,\nmaterial retested, however, and it meets, for example, class 8,\npacking group Ill, a proper shipping name then must be selected\nIrom the generic or n.o.s. descriptions corresponding to the\nspecific hazard class\nand packing group for the material and it\napplicable requirements.\nmust be offered for transportation in accordance with the\n.-\n\n<<<PAGE 2>>>\n\nI hope this satisfies your inquixy. Also, I have enclosed some\n•\ninformational material.\nfurther assistance.\nPlease contact us if we can be of\nSincerely,\nHatte z. Mitchell\nHattie I. Mitchell, Chief\nRegulatory Review and Reinvention\nOffice of Hazardous Materials Standards\n\n<<<PAGE 3>>>\n\n0598-8-18:10:11 AM: 206 (#\n;03 3275 2206\n11 2DHM\n98-0248\nTELEX: 2222235 LACHEMS\nTELEPHONE +03-3274-5501\nMusashino\nFAX: 03-3272-4366\nChemical Laboratory;Ltd.\n1-1, KYOBASHI 1 CHOME, CHUO-KU\nYAESU•DAIBIRU BLDG.\nTOKYO 104 JAPAN\n•.\n-0031\nStevens\nDate\n: August\n$172,101 (k)\nTo\n18th, 1998\n: US Department of Transportation\nLactic Acid\nAt t n.\n: Mr. Edward\nT. MAZZULLO\n:\nDirector, Office of Hazardus Materials\nStatement\n'From\n: YUKAWA Muneaki/\nManager of Teahnical Department\nRe\n: Lactic Acid\nDear Mr. Mazzullo, .\nexporting laotic acid and its derivatives\nworldwidely.\nRecently we have had your opinion that lactic\nas restad, is not\na corrosivo\nmaterial: based on the definition for \"correstro\nat 49 CFR 173.136, test\ncriteria to\ndetermine the packing group of Class 8 material\nHowever we understand ihat lactic acid is a\norrosive material based on the 1992 OECD Guide\nfor Testing of Chemicals Number 404 Acute\nDormal Irritation/Corrosion\" which\nis attached.\nwould like to take your comment whether\nLactic acid\nis a\ncorrosive or not.\nPlease\ninform us your opionion for lactic acid.\nBest regards\nTEMPE\najutawam,\n\n<<<PAGE 4>>>\n\n198-8-18;10:11AM; #80 (#) #\n:03 3275 2206\n#\n2/2\n2404•\n7217.07.92\nAdopted\nFOECD GUIDELINE FOR TESTING OF CHEMICALS\nDcp: Organization for Ecomonic Cooperation end deme lime;\nAdopted by the Council on 17\"' July 1992\n•:\nAcute Dermal Irritation/Corrosion\nINTRODUCTION\nprogress. In the review, special attention is given to possible improvements in relation to animal\nOECD Guidelines for Testing of Chemicals are periodically reviewed in light of scientific\nwelfare. This updated version of the original guideline 404 (adopted in 1981) is the outcome of a\nmeeting of OECD experts held in Paris in May 1991.\n; •\ninclusion of data from in vitro tests in the information on which a decision not to proceed to an in vivo.\nThe main differences between this and the original version of the guideline are: a) the\nallowing certain chemicals to be exempted from further testing.\ntest can be based; and b) the possibility to use one animal in a first step of the in vivo procedure\n3.\nDefinitions used are set out in the Annex.\nINITIAL CONSIERATIONS\n4.\navoided, and that any testing which is likely to produce severe responses in animals is minimised.\nIn the interests of animal welfare, it is important that the winecessary use of animals is\nConsequently, test materials meeting any of the following criteria should not be tested in animals for\ndermal irritation/corrosion:\ni)\nmaterials that have predictable corrosive potential based on structure-activity\nrelationships and/or physicochemical properties such as strong acidity or alkalinity,\nor acidic reserve (1) should also be taken into account);\ne.g., when the material to be applied has a pit of 2 or less or 11.5 or greater (alkaline\nịi)\nmaterials which have been shown to be highly toxic by the dermal route;\niii)\nmaterials which, in an acute dermal toxicity test (2), have been shown not to produce\nirritation of the skin at the limit test dose level of 2000 mg/kg body weight.\npredicted on the basis of results from in vitro tests (3).\nIn addition, it may not be necessary to test in vivo materials for which corrosive properties are\nPRINCIPLE OF THE IN VIVO TEST •\n5. * The substance to be tested is applied in a single dose to the skin of one or more experiatental\nanimals, untreated skin areas of the test animal (s) serving as control. The degree of irritation is read\n1/6\n...","truncated":false,"body_characters":5613}