{"operation":"document","citation":"99-0240","title":"Dangerous Goods of America, Inc. — Hazardous Materials Safety Interpretation","source_type":"guidance","agency":"Pipeline and Hazardous Materials Safety Administration","status":"guidance","official":true,"published_on":"2000-04-20","effective_on":null,"summary":"99-0240 response to Dangerous Goods of America, Inc. concerning 173.132.","machine_formats":{"json":"https://regulus.evalyn.ai/document/phmsa-interpretation-99-0240.json","markdown":"https://regulus.evalyn.ai/document/phmsa-interpretation-99-0240.md"},"app_url":"https://regulus.evalyn.ai/document/phmsa-interpretation-99-0240","source_url":"https://www.phmsa.dot.gov/sites/phmsa.dot.gov/files/legacy/interpretations/Interpretation%20Files/1999/990240.pdf","body":"<<<PAGE 1>>>\n\n15. Departmer\nf Transportation\nWashington, D.C.\n400 Seventh Street. S.W.\n20590\nResearch and\nIdministratior\npecial Program:\nAPR 2 0 2000\nMr. Valois Pagan III\nConsultant\nReference No. 99-0240\nDangerous Goods of America, Inc.\nP.O. Box 590888\nMiami, FL 33159-0888\nDear Mr. Pagan:\nThis is in response to your letter concerning what types of laboratory animals are\nacceptable for determining the oral and dermal toxicity and packing group for a Division\n6.1 material under the Hazardous Materials Regulations (HMR; 49 CFR Parts 171-180).\nI have paraphrased your questions and answered them in the order provided.\nQ1.\nSection 173.132 states that the toxicity test is to be performed on \"albino rats.\" If\na material safety data sheet (MSDS) for a product shows that the tests were\nperformed on rats, mice, or rabbits, may this information be used to determine the\nPacking Group?\nA1.\nTypically, when a toxicity test is performed requiring the use of albino rats, a\nlaboratory performs the test on albino rats but states for convenience that the test\nwas performed on \"rats\" in its literature for public distribution describing the\nresulting classification. A description of the types of rats used can usually be\nfound in the laboratory's hazard classification test report on the material. If the\nobtain additional information.\nreport does not contain this information, you should consult the laboratory staff to\nWe do not accept toxicity tests performed on mice. A material that meets one or\nlore of the LDso or LCso criteria for oral, dermal, or inhalation toxicity as a resu\nf testing in accordance with $ 173.132 meets the definition of a poisonou\nmaterial (Division 6.1). As stated in § 173.132(b), albino rabbits are to be used\nto test for dermal toxicity and albino rats are to be used for oral or inhalation\ntoxicity. Animal test data that has been reported in chemical literature should be\nused whenever possible. Under § 173.133, the shipper assigns the material a\nPacking Group based on these results.\n990240\n\n<<<PAGE 2>>>\n\nAn MSDS for a product shows that the toxicity tests were performed on rats, but\nnot specifically \"albino rats,\" and rabbits. If the rat specimen test results show the\nproduct is not regulated but the rabbit specimen test results show the product is a\nDivision 6.1, Packing Group III material, is this product regulated under the\nHMR? Why?\nA2. See our response in Al.\nI hope this satisfies your request.\nSincerely,\nHotter. Mitchelp\nHattie L. Mitchell, Chief\nRegulatory Review and Reinvention\nOffice of Hazardous Materials Standards\n2\n\n<<<PAGE 3>>>\n\nDANGEROUS GOODS OF AMERICA, INC.\nPO BOX 590888 + MIAMI, FL 33159-0888 • USA\n-MAIL: info@dangerousgoods.net + WEB SITE: www.dangerousgoods.ne\nPhone (305) 871-3313 • Fax (305) 871-138\nMr. Edward Mazzulo\nDepartment of Transportation\nMack\n§173,132\n99-0240\nAugust 19, 1999\nDear Mr. Mazzulo,\n6.1 Toxic substances, more specifically, oral and dermal toxicity.\nBelow I have asked two questions in reference to packing group criteria with respect to Division\nQ: Subpart 173.132 of CFR-49 states that the LDso toxicity tests are performed on \"albino rats\".\nIf an MSDS shows only information for other rodents like rats, mice and/or rabbits, and not\nGroups?\nspecifically \"albino rats\", can this information be used to determine respective Packing\nQ2: Subpart 173.132 of CFR-49 states that the LDso toxicity tests are performed on \"albino rats\".\nIf an MSDS shows the toxicity tests results for two rodents, a rat and a rabbit, not\nis not regulated, according to the information given on the rabbit (for the same substance)\nspecitically stating \"albino rat\", according to the information given for the rat, the substance\nwhy not?\nthe substance would be considered Packing Group I!!, is this product regulated? Why or\nPlease respond in writing to:\nMr. Val Pagan\nDangerous Goods of America\nPO Box 590888\nMiami, FL 33159\nPlease do not hesitate to contact our office should you have any questions.\nBest regards,\nConsultant\nOFFICE & WAREHOUSE FACILITIES • 1651 NW 68'\" AVE • CARGO BLDG 706 • SUTE 213","truncated":false,"body_characters":4069}