World Heart, Inc. — Hazardous Materials Safety Interpretation

Page 1S. Departmer Transportatic 100 Seventh St., Sv Nashington, D.C. 2059 JUL 1 3 2001 Ms. Carol McCulley Explant Services Reference No.: 01-0120 World Heart, Inc. 7799 Pardee Lane Oakland, CA 94612 This is in response to your May 10, 2000 letter requesting clarification of the proper shipping name for a Formaldehyde solution containing 10% neutral buffered formalin under the Hazardous Materials Regulations (HMR; 49 CFR Parts 171-180). Specifically, you ask whether "Aviation regulated liquid, n.o.s." the proper shipping name should be "Environmentally hazardous substances, liquid, n.o.s." or Either shipping name may be used, however, the preferred proper shipping name is "Aviation regulated liquid, n.o.s." The entry "Aviation regulated liquid, n.o.s." was added to the § 172.101 Hazardous Materials Table in a final rule published March 5, 1999 (Docket HM-215C; 64 FR 10741) for alignment with the ICAO Technical Instructions and the UN Recommendations. I trust you find the information helpful. Sincerely, Hotle 2. Mittel Hattie L.Mitchell Chief, Regulatory Review and Reinvention Office of Hazardous Materials Standards#

Page 2Corbin $172.101 WORLDHE RT ma Proper Shipping hime 10 May, 2000 Attention: Edward Mazzulo Director of Hazardous Materials Standards Department of Transportation 400 7th Street, SW Washington, D.C. 20590 Dear Mr. Mazzulo: We provide a shipping box for our customers to return our Left Ventricular Assist Device when it is removed from a patient. The box contains a total amount of approximately 560 ml of 10% neutral buffered formalin in five containers when returned to us. We do not provide the 10% neutral buffered formalin. Currently, our shipping information is: Environmentally hazardous substances, liquid, 1.o.s. (formaldehyde), UN3082, packing group III, hazard class 9. I have MSDS forms from various manufacturers of 10% neutral buffered formalin. They disagree as to the proper shipping name and UN classification. I have been informed by the manufacturer of the shipping box we use that the correct information should now be: Aviation regulated liquid, n.o.s. (10% buffered formalin), UN3334, no packing group, hazard class 9. We would appreciate confirmation that Aviation regulated liquid, n.o.s. (10% buffered formalin) UN3334, no packing group, hazard class 9 is the proper shipping name/description and shipping information. Thank you very much. Regards, Carlie-ally, Carol McCulley Explant Services World Heart, Inc. (510) 563-4971 (phone) (510) 569-4914 (fax) carol.mcculley@worldheart.com (e-mail) Attachments: 4 MSDS forms from various manufacturers#

Page 3... WORLD HEART INC WORLDHE RT OAKLAND. CA 84821 1SA 7709 PARDEE LANE TEL. 510-363-5000 FAX. 310•303•3005 Department of Transportation Director of Hazardous Materials#

Page 4...- SIGMA-ALDRICH Material Safety Data Sheet Date upated: 0027/2000 Version 1,20 Section 1 - Product and Company Information Product Number Product Name FORMALDEHYDE Brand Sigma Chemical F1635 Company Street Address Sigma-Aldrich Technical Phone: City, State, Zip, Country 3050 Spruce Street St. Louls, MO 63103 US Fax: 314 771 5765 800 325 5052 Emergency Phone: 414 273 3850 Ext.5996 Section 2 - Composition/Information on Ingredient FORMALDEHYDE Substance Name 60-00-0 SARA 313 Yes Formula Synonyms CH2O Aldehyde formique (French), Aldehyd mravenci (Czech), Aldeide formica (Italian), BFV, Fannofom -ormaldehyde (ACGIH:OSHA), Formaldehyd (Czech, Polish), Formaldehyde, gas, Formalin, Section 3 - Hazards Identification Toxic. Emergency Overview Toxic by Inhalation, in contact with skin, and if swallowed. Causes bums. May cause sensitizaton by inhalation and skin contact. Potential cancer hazard. Contains formaldehyde. Readily absorbed through skin. Lachrymator. Combustible liquid. Target organ(s): Possible risk of irreversible effects. May cause heritable genetic damage. Health: 3* HMIS Rating •Flammability: 2 Reactivity: 1 Health: 3 NFPA Rating Flammability: 2 Reactivity: 1 *additional chronic hazards present. For additional information on toxicity, please refer to Section 11. Section 4 - First Aid Measures If swallowed, wash out mouth with water provided person is conscious. Call a physician immediately. Oral Exposure Inhalation Exposure If inhaled, remove to fresh air. It not breathing give artificial respiration. if breathing is difficult, give oxygen. - •#

Page 5• In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a Dermal Exposure physician. in case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the Eye Exposure eyelids with fingers. Call a physician. Section 5 - Fire Fighting Measures Flash Point: 147.2°F 64 °C Explosion Limits: - NoT Chan! Lower: 7% Upper: 73% Autoignition Temp: 300 °C Class 3! castiar Extinguishing Media Suitable Carbon dioxide, dry chemical powder, or appropriate foam. Firelighting Protective Equipment Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes. Specific Hazard(8) Specific Method(8) of Fire Fighting Combustible lIquid. Emits toxic fumes under fire conditions, Use water spray to cool fire-exposed containers. Section 6 - Accidental Release Measures Evacuate area. Procedure to be Followed in Case of Leak or Spill /ear self-contained breathing apparatus, rubber boots, and heavy rubber glove rocedure(s) of Personal Precaution(t Cover with dry lime or soda ash, pick up, keep in a closed container, and hold for waste disposal. Ventilate area and wash spill site Methods for Cleaning Up after material pickup is complete. Section 7 - Handling and Storage Handling User Exposure Do not breathe vapor. Do not get in eyes, on skin, on clothing. Avold prolonged or repeated exposure. Storage Suitable • man Keep tightly closed. Keep away from heat and open flame. Store in a cool dry place. Section 8 - Exposure Controls / PPE Engineering Controls : Use only in a chemical fume hood, Safety shower and eye bath. Personal Protective Equipment Respiratory Hand NIOSH/MSHA-approved respirator. Compatible chemical-resistant gloves. Page 2 Sigma Chemical - F1635 Sigma-Aldrich Corporation www.oigma-aldrich.com -#

Page 6• Chemical safety goggles. Eye Other Faceshield (8-inch minimum). ash Contamient eating before reus. Discard conkaminated shoes. Wash thoroughly after handling. Exposure Limits, RTECS USA Country ACGIH Source LYDE Celllry Value USA MSHA Standard concentration 0.37 MG/M3 (0.3 PPM) Remarks Celling 2 PPM (3 MG/M3) • New Zealand USA OEL OSHA. percentration SEE 1910.1048 USA NIOSH TWA Celling concentration 0.016 PPM 0.1 PPM/15M check ACGIH TLV Section 9 - Physical/Chemical Properties Appearance Liquid Physical State Color Coloress Clear liquid Form Molecular Weight: 30.03 AMU Property Value At Temperature or Pressure pH MP/MP Range BP/BP Range N/A N/A Freezing Point N/A N/A Vapor Pressure Vapor Density 1.03 g/l 52 mmHg 37 °C SG/Density Saturated Vapor Conc. N/A Bulk Density N/A 1.016 g/cm3 Volatile% Odor Threshold N/A Water Content VOC Content N/A N/A Evaporation Rate Solvent Content N/A N/A Viscosity N/A Partition Coefficient N/A N/A Been Pointion Temp. N/A Flash Point °C 147.2 °F Explosion Limite Lower: 7% 64 °C Refractive Index Autoignition Temp Upper: 73% 300 °C Solubility 1.339 N/A Sigma Chemical - F1635 Page 3 Sigma-Aldrich Corporation : www.sigma-aldrich.com#

Page 7• Section 10 - Stability and Reactivity Stability Stable Stable. Materials to Avoid Peroratible with aniline, phenol, locyanates, anhydrides, Strong acids, Strong bases, Strong oxidizing agents, Amines, Hazardous Decomposition Products Hazardous Decomposition Products Carbon monoxide, Carbon dioxide. Hazardous Polymerization Will not occur. Hazardous Polymerization Section 11 - Toxicological Information oute of Exposur kin Contac Causes burns. Skin Absorption Readily absorbed through skin. Toxic if absorbed through skin. Causes burns. Eye Contact Inhalation Ingestion Toxic if inhaled. Material is extremely destructive to the tissue of the mucous membranes and upper respiratory tract. affecting the ability to breathe, circulatory shock, and convulsions. Toxic if swallowed. Ingestion can cause immediate burning pain in the mouth, throat, abdomen; severe swelling of the larynx and skeletal paralysis Sensitization Sensitization May cause allergic respiratory and skin reactions Eyes, Kidneys, Liver. Heart. Target Organ(s) or Systems) Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and skin. Inhalation may result Signs and Symptoms of Exposure in spasm, inflammation and edema of the larynx and bronchi, chemical pneumonitis, and pulmonary edema. Symptoms of exposure cause: Coughing, chest pains, difficulty in breathing. Gastrointestinal disturbances. May cause convulsions. To the best of our may include buming sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting, Exposure can knowledge, the chemical, physical, and toxicological properties have not been thoroughly Investigated. RECS Number: LP8925000 ...... Toxicity Data Oral - Woman: 108 mg/kg (LDLO) - •• Oral - Woman: 1 ML/KG (LDLO) Remarks: Behavioral:Coma. Gastrointestinal:Alteration in gastric secretion. Cardiac:Other changes. Oral - Rat: 100 mg/kg (LD50) Page 4 Sigma Chemical - F1635 Sigma-Aldrich Corporation www.sigma-aldrich.com#

Page 8•. Subcutaneous - Rat: 420 MG/KG (LD50) Remarks: Lungs, Thorax, or Respiration:Acute pulmonary edema. Lungs, Thorax, or Respiration:Broncholar constriction. Intravenous - Rat: 87 MG/KG (LD50) Oral - Mouse: 42 mg/kg (LD50) Remarks: Behavioral:Somnolence (general depressed activity). Behavioral:Convulsions or effect on seizure threshold. Behavioral:Excitement. Inhalation - Mouse: 454,000 mg/m3 (LC50) Subcutaneous - Mouse: 300 MG/KG (LD50) Remarks: Lungs, Thorax, or Respiration:Acute pulmonary edema. Lungs, Thorax, or Respiration:Bronchiolar constriction, Skin - Rabbit: 270 UL/KG (LD50) Oral - Guinea pig: 260 mg/kg (LD50) Irritation Data Skin - Human: 0.15 mg 3D | Remarks: Mild irritation effect Eyes - Human: 4 ppm 5M Eyes - Human: 1 ppm SM Remarks: Mild irritation effect Skin - Rabbit: 2 mg 24H Remarks: Severe irritation effect Skin - Rabbit: 540 mg Remarks: Open irritation test Skin - Rabbit: 50 mg 24H Remarks: Moderate irritation effect Eyes - Rabbit: 0.75 mg 24H Remarks: Severe Irritation effect Eyes - Rabbit: 0.75 mg Remarks: Severe imitation effect Eyes - Rabbit: 10 mg Remarks: Severe irritation effect Chronic Exposure Carcinogen Result: This product is or contains a component that has been reported to be possibly carcinogenic based on its ARC, ACGIH, NTP, or EPA classification. Rat - Oral: 109 GM/KG 2Y C Result: Tumorigenic: Carcinogenic by RTECS criteria, Gastrointestinal:Tumors. Blood:Leukemia Rat - Inhalation: 14300 PPB 6H/2Y 1 Hes: Tumorge:Carcingenle by RECS criteria. Sense Organs and Special Senses (Nose, Eye, Ear, and Taste): Olfaction: Tumors. -.. un... Result: Tumorigenic: Equivocal tumorigenic agent, by. RECS criteria. Tumorigenic: Tumors at site or application. Rat - Subcutaneous: 1170 MG/KG 65W 1 Mouse - Inhalation: 14300 PB 6H/2Y | Result: TumorigencEquivocal tumorigenic agent by RTECS criteria, Sense Organs and Special Senses (Nose, Eye, Ear, and Taste): Olfaction: Tumors. Rat Inhalation: 15 PM 64/78W 1 Taste):Olfaction:Tumors. Result: Tumorigenic:Carcinogenic by RECS cnteria. Sense Organs and Special Senses (Nose, Eye, Ear, and Rat Subtaneous: 350 MG/ 78W | Result: Tumorigenic:Equivocal tumorigenic agent by RTECS criteria, Skin and Appendages: Other: Tumors. Tumorigenic:Tumors at site or application. Page 5 Sigma Chemical - F1635 Sigma-Aldrich Corporation www.sigma-aldrich.com - •#

Page 9.. Rat - Inhalation: 6 PPM 6H/2Y | Result: Tumorigenic:Equivocal tumorigenic agent by RTECS criterla. Sense Organs and Special Senses (Nose, Eye, Ear, and Taste):Olfaction:Tumors. Rat - Inhalation: 15 PM 6H/86W 1 Resuit: Tumorigenic:Carcinogenic by RTECS criteria. Sense Organs and Special Senses (Nose, Eye, Ear, and Taste): Olfaction: Tumors. Rat - Inhalation: 14 PPM 6H/84W | Result: Tumorigenic: Carcinogenic by RTECS criteria. Sense Organs and Special Senses (Nose, Eye, Ear, and Taste):Olfaction:Tumors, Rat - Inhalation: 18750 UG/M3 2Y- | Result: Tumorigenic: Equivocal tumorigenic agent by RECS criteria. Sense Organs and Special Senses (Nose, Eye, Ear, and Taste):Olfaction:Tumors. Mouse - Inhalation: 15 PM 6H/104W 1 Result: Tumorigenic: Equivocal tumorigenic agent by RTECS criteria. Sense Organs and Special Senses (Nose, Eye, Ear, and Taste): Olfaction: Tumors. Rat - Inhalation: 15 PPM 6H/2Y | Result: Tumorigenic: Carcinogenic by RTECS criteria, Sense Organs and Special Senses (Nose, Eye, Ear, and Taste):Olfaction:Tumors. Rat - Inhalation: 5600 PB HRY | Result: Tumorigenic: Equivocal tumorigenlc agent by RTECS criteria. Sense Organs and Special Senses (Nose, Eye, Ear, and Taste):Olfaction:Tumors. OSHA Carcinogen List Patential cancer hazard. LARC Carcinogen List Rating Group 2A NTP Carcinogen List Rating Anticipated to be a carcinogen. ACGIH Carcinogen List Rating A2 Chronic Exposure - Teratogen Species Rat Route of Application Exposure Time Rosul-Specie Development Abnormies Headilary system. (1-21D PREG) Rat Resut lets on My relus: Cylogic lange induting somalie el genetie materia. 1 MG/3/24H Rat 500 UG/M3/4H (1-19D PREG) Rat Result:Specific Developmental Abnormalities: Hepatobiliary system. 168 MG/KG Oral (1-21D PREG) Mouse (7-14D PREG) Spect Desomena porales raid a prince su on gu. Mouse Specific Developmental Abnormalities: Musculoskeletal system. Result: Effects on Embryo or Fetus: Fetal death. 240 MG/KG Intraperitoneal (7-14D PREG) Mouse ResultSpectic DeVelopmental Abnormalities: other developmental abnomil PREG) 160 MG/KG Intraperitoneal Page 6 Sigma Chemical - F1635 Sigma-Aldrich Corporation www.sigme-aldrich.com -#

Page 10• Species Chronic Exposure - Mutagen Result: May aer genetic materialute Exposure Time Cell Type Mutation test - Sigma Chemical - F1635 Page 7 igma-Aldrich Corporatic ww.sigma-aldrich.cr#

Page 11• DNA damage lung DNA damage DNA damage DNA damage Unscheduled DNA synthesis DNA inhibition DNA inhibition Other mutation test systems Cytogenetic analysis Other mutation test systems Cytogenetic analysis • Sister chromatid exchange Oral 30H Micronucieus test Mutation In mammalian somatic cells. • - 3Н Inhalation liver DNA damage Morphological transformation. Oral DNA damage DNA damage DNA damage DNA damage Oral Unscheduled DNA synthesis Siver Unscheduled DNA synthesis Unscheduled DNA synthesis DNA inhibition 500 Inhalation Cytogenetic analysis Other mutation test systems Inhalation Intraperitoneal 5D Intraperitoneal Oral 5D Dominant lethal test Cytogenetic analysis 5D spem sperm Mutation In microorganisms DNA damaga Morphological transformation. Oral Cytogenetic analysis DNA damage Intraperitoneal Mutation in mammalian somatic cells. Cytogenetic analysis Morphological transformation. Host-medlated assay Morphological transformation. DNA damage Cytogenetic analysis Phage inhibition capacity Cytogenetic analysis Sister chromatid exchange Sister chromatid exchange DNA damage Mutation In mammalian somatic cells. Intratesticular sperm - - Ф DNA DNA damage Sigma Chemical - F1635 Page 8 Sigma-Aldrich Corporation www.sigma-aldrich.com -#

Page 12.. Chronic Exposure - Reproductive Hazard Species Rat Dose 200 MG/KG Route of Application Oral Expasure Time (1D MALE) Rat Result: Paternal Effects: Spermatogenesis (including genetic material, sperm morphology,motility, and count). Result: Effects on Newborn: Biochemical and metabolic. 168 MG/KG (1-21D PREG) Rat 12 UG/M3/24H inhalation PREG) (15D PRE/1-22D effects. Result: Effects on Newborn: Growth statistics (e.g., reduced weight gain). Effects on Newborn: Other postnatal measures or Rat 12 UG/M3/24H Inhalation (1-22D PREG) Rat Result: Effects on Newborn: Biochemical and metabolic. Result: Paternal Effects: Spermatogenesis (including genetic material, sperm morphology,motility, and count), Paternal 35 UG/M3/8H Inhalation (BOD MALE) Rat Effects: Other effects on male. Inhalation PREG) (20D PRE/1-22D Rat Result: Effects on Newborn: Biochemical and metabolic. 80 MG/KG Result: Pateral Elects: Testes, epididymis, sperm duct. Paternal Effects: Prostate, seminal vessicle, Cowper's gland, Intraperitoneal (10D MALE) Rat accessory glands. Result: Patemal Effects: Testes, epicidymis, sperm duct. 46243 MG/KG Subcutaneous (20D MALE) Rat Result: Effects on Merily: Male fertily die a t males imprep ating males per it males exposed to fertile nonpregnant females). Result: Paternal Effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count). 500 MG/KG Result: Effects on Feiny: Post implantation oraly (a g, dead and or resorbed implanka per total number of Implants). Dog Effects on Embryo or Fetus: Fetal death. Result: Paternal Effects: Testes, epididymis, sperm duct. 7 MG/KG Intratesticufar (1D MALE) Monkey 4 MG/KG Intratesticular (1D MALE) Domestic Result: Paternal Effects: Spermatogenesis (Including genetic material, sperm morphology, motility, and count). Animals 6687 UG/KG Intratesticular (1D MALE) Result: Paternal Effects: Spermatogenesis (Including genetic material, sperm morphology, motility, and count). Patemal Effects: Testes, epididymis, sperm duct. Section 12 - Ecological Information Section 13 - Disposal Considerations Appropriate Method of Disposal of Subetance or Preperation contact a licensed professional waste disposal service to dispose of this material. •. Observe all,tederal, state, and local environmental regulations. Dissolve or mix the material with a combustible solvent and burn in a chemical Incinerator equipped with an afterburner and scrubber Section 14 - Transport information "DOT— UN#: 1198 Proper Shipping Name: Formaldehyde, solutions, flammable Class: 3 pa face 472F PIH: Not PIH Packing Group: Packing Group Ill • Not Class 3! LATA Proper Shipping Name: Formaldehyde solution, flammable Hazard Class: 3 IATA Number: 1198 Packing Group: III Page 9 Sigma Chemical - F1635 Sigma-Aldrich Corporation www.sigma-aldrich.com#

Page 13Section 15 - Regulatory Information EU Directives Classification Indication of Danger Symbol of Danger: T Toxic. Rick Statements Toxic by inhalation, in contact with skin, and if swallowed. Causes burns. Possible risk of irreversible effects. May cause R: 23/24/25 34 40 43 Safety Statements In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves. Wear eye/ace protection. in case of accident or if you feel unwell, seek medical advice Immediately (show the label where possible). Use only in well ventilated areas. US Classification and Label Text . Toxic. Indication of Danger Risk Statements Toxic by inhalation, in contact with skin, and If swallowed. Causes burns. May cause sensitization by inhalation and skin contact. Possible risk of Irreversible effects. May cause heritable genetic damage. Safety Statements In case or coat ire in ran ay with or you we rand e neil dice maritaly her the take who. US Statements possible). Use only in well ventilated areas. Potential cancer hazard. Contains formaldehyde, Readily absorbed through skin. Lachrymator. Combustible liquid. Target organ(s): Eyes. Kidneys. Listed: Yes United States Regulatory Information Deminimis: 0.1 % Notes: This product is subject to SARA section 313 reporting requirements. TSCA Inventory Item: Yes California Prop - 65 United States - State Regulatory Information Proposition 65: This product is or contains chemical(s) known to the state of California to cause cancer. California Proposition 65: This product is or contains chemical(s) known to the state of California to cause cancer. Califomia Section 16 - Other Information unlimited paper copies for internal use only. • Sigma Chemical - F1635 Page 10 Sigma-Aldrich Corporation www.sigma-eldrich.com -#

Page 14Emergency Tacon: 420 350 54.065 SIGMA-ALDRICH www.sigma-aidrich.com Fax: 800 325 5052 4/18/01 Sigma-Aldrich MSDS The MSDS that surpasses them all. The MSDS for more than 85,000 Sigma, Aldrich, Fluka, Supelco, and Riedel-de Haen chemicals on compact disc or magnetic tape. MSDS are arranged in 16 chapter format and are available in six languages: • English • Dutch * German • French Italian • Spanish updated safety information. The CD-ROM includes versions for Microsoft Window...etc. Subscribers receive quarterly updates on a new CD-ROM or magnetic tape that includes new products and To order call your local Sigma-Aldrich office or visit www.sigma-aldrich.com www.sigma-aldrich.com has a new look! We have made some exciting upgrades to our website as well as given it a new look. Some of the things familiarize yourself with our new, more unified, navigation system. you've been familiar with are improved upon and have possibly been relocated. Please take some time to • Weare Committed to the Succees of our Customers; Employees and Shareholdera through Life Sclence, Technology and Service.#

Page 15• St. Louis, MO 63103 U 3050 Spruce Stree Technical Phone: 314 771 5765 SIGMA-ALDRICH Emergency Phone: 414 273 3850 Ex. 5096 www.sigma-aidrich.com Fax: 800 325 5052 7799 PARDEE LN CAROL MCCULLEY 4/18/01 US OAKLAND, CA 94621 Phone number: 5105634971 Fax: 5105694914 Dear Sigma-Aldrich Customer We recently reorganized our MSDS to better serve you, our valued customer. In addition to an updated look, our sheets now feature a revision date, NFPA/HMIS ratings, and transportation Information. you have any questions or comments As always, customer service is our top priority. Please contact the MSDS department toll-free at 800-521-8956 ext. 2143 i MSDS Reference Number: P10515789 Attached please find the Material Safety Data Sheets you requested. Material: Sigma Chemical - F1635 FORMALDEHYDE Substance: 50-00-0 FORMALDEHYDE SARA 313: Yes - We are Committed to the Success of our Customers, Employees and Shareholders through Life Sclence, Technology and Sorvice.#

Page 16- Material Safety Data Sheet 10 % Buffered Formalin ACC# 41129 Section 1 - Chemical Product and Company Identification MSDS Name: 10 % Buffered Formalin Synonyms: None. Catalog Numbers: SF99 20, SF99 4, SF9920, SF994 - Company Identification: Fisher Scientific Fair Lawn, NJ 07410 1 Reagent Lane For information, call: 201-796-7100 Emergency Number: 201-796-7100 For CHEMTREC assistance, call: 800-424-9300 For International CHEMTREC assistance, call: 703-527-3887 Section 2 - Composition, Information on Ingredients CAS# Chemical Name 50-00-0 Percent EINECS/ELINCS Formaldehyde 67-56-1 3.9-4.0 Methyl Alcohol 200-001-8 2.0 % 127-09-3 200-659-6 Sodium Acetate 7732-18-5 1.2-2.0 Water Balance 204-823-8 231-791-2 Section 3 - Hazards Identification EMERGENCY OVERVIEW Appearance: not available, Flash Point: > 194 deg F. Danger! May cause allergic respiratory fetal effects in animals. May cause central nervous system depression. Causes eye and skin reaction. May cause allergic skin reaction. This substance has caused adverse reproductive and irritation. Causes digestive and respiratory tract irritation. Contains formaldehye. Potential Target Organs: Central nervous system. Potential Health Effects Eye: Causes eye irritation. Skin: Causes skin irritation. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material. Ingestion: Cannot be made non-poisonous. May cause central nervous system depression, kidney damage, and liver damage. Causes gastrointestinal irritation with nausea, vomiting and diarrhea. Inhalation: Causes respiratory tract irritation. May cause allergic respiratory reaction. Chronic: May cause cancer according to animal studies. May cause reproductive and fetal effects. https://fscimage.fishersci.com/msds/41129.htm 4/18/01#

Page 17- Section 4 - First Aid Measures the upper and lower eyelids. Get medical aid. Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting Skin: Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Ingestion: Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or Inhalation: Remove from exposure to fresh air immediately. If not breathing, give artificial water. Never give anything by mouth to an unconscious person. Get medical aid. respiration. If breathing is difficult, give oxygen. Get medical aid. • Notes to Physician: Treat symptomatically and supportively. Section 5 - Firefighting Measures General Information: As in any fire, wear a self-contained breathing apparatus in pressure- and highly toxic gases may be generated by thermal decomposition or combustion. demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating Extinguishing Media: For small fires, use dry chemical, carbon dioxide, water spray or alcohol- resistant foam. Cool containers with flooding quantities of water until well after fire is out. Section 6 - Accidental Release Measures General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Absorb spill with inert material, (e.g., dry sand or earth), then place into a Equipment section. chemical waste container. Clean up spills immediately, observing precautions in the Protective Section 7 - Handling and Storage .._Handling: Wash thoroughly after handling. Wash hands before eating. Use only in a well- ingest or inhale. ventilated area. Do not get in eyes, on skin, or on clothing. Keep container tightly closed. Do not incompatible substances. Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from Section 8 - Exposure Controls, Personal Protection Engineering Controls: Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits. Exposure Limits https://fscimage.fishersci.com/msds/41129.htm 4/18/01#

Page 18• - Chemical Name ACGIH NIOSH OSHA - Final PELs 0.016 ppm TWA; NIOSH Formaldehyde C 0.3 ppm Potential Occupational Appendix A Potential Carcinogen - see ppm STEL; 0.5 ppm TWA 0.75 ppm TWA PEL; 2 NIOSH carcinogen. action leve Methyl Alcohol 200 ppm; 250 ppm STEL; cutaneous absorption skin - potential for 200 ppm TWA; 260 mg/m3 TWA 6000 ppm 200 ppm TWA; 260 Sodium Acetate .IDLH mg/m3 TWA Thone listed none listed none listed Water /none listed none listed none listed OSHA Vacated PELs: Formaldehyde: 3 ppm TWA (unless specified in 1910.1048) Methyl Personal Protective Equipment OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure necessary. Section 9 - Physical and Chemical Properties Physical State: Liquid Odor: None reported Appearance: not available pH: Not available. Vapor Pressure: Not available. Vapor Density: Not available. Evaporation Rate:Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point:Not available. Decomposition Temperature:Not available. Autoignition Temperature: Not applicable. Flash Point: > 194 deg F (> 90.00 deg C) NFPA Rating: Not published. Explosion Limits, Lower:Not available. Upper: Not available. Solubility: Soluble in water. Specific Gravity/Density:Not available. Molecular Formula: Mixture Molecular Weight:Not applicable. Section 10 - Stability and Reactivity • rai -Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Incompatible materials, excess heat. https://fscimage.fishersci.com/msds/41129.htm 4/18/01#

Page 19- incompatibilities with Other Materials: Strong oxidants. lazardous Decomposition Products: Irritating and toxic gases lazardous Polymerization: Has not been reported Section 11 - Toxicological Information RTECS#: CAS# 50-00-0: LP8925000 CAS# 67-56-1: PC1400000 CAS# 7732-18-5: ZC0110000 CAS# 127-09-3: A14300010 LD50/LC50: CAS# 50-00-0: Inhalation, mouse: LC50 =400 mg/m3/2H; Inhalation, rat: LC50 =203 mg/m3; Oral, mouse: LD50 = 42 mg/kg; Oral, rat: LD50 = 100 mg/kg; Skin, rabbit: LD50 = 270 mg/kg; CAS# 67-56-1: Inhalation, rat: LC50 =64000 ppm/4H; Oral, mouse: LD50 = 7300 mg/kg; Oral, rabbit: LD50 = 14200 mg/kg; Oral, rat: LD50 = 5628 mg/kg; Skin, rabbit: LD50 = 15800 mg/kg; CAS# 127-09-3: Oral, mouse: LD50 = 6891 mg/kg; Oral, rat: LD50 = 3530 mg/kg; CAS# 7732-18-5: Oral, rat: LD50 = >90 mL/kg; Carcinogenicity: CAS# 50-00-0: ACGIH: A2 - suspected human carcinogen California: carcinogen; initial date 1/1/88 NIOSH: occupational carcinogen NTP: Suspect carcinogen OSHA: Possible Select carcinogen TARC: Group 2A carcinogen CAS# 67-56-1: Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA. CAS# 127-09-3: Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA. CAS# 7732-18-5: Not listed ... by ACGIH, IARC, NIOSH, NTP, or OSHA. Epidemiology: No information available. biochemical/metabolic and reduced weight gain, ihl-rat TCLo=12 ug/m3/24H. Embryo or Fetus: Teratogenicity: Formaldehyde effects on Newborn: behavioral, ihl-rat TCLo=50 ug/m3/4H; cytological changes, ihl-rat TCLo=1 mg/m3/24H; stunted fetus and death, ipr-mouse TDLo=240 mg/kg. Specific Developmental Abnormalities: craniofacial and musculoskeletal, ipr-mouse TDLo=240 mg/kg. Reproductive Effects: Formaldehyde effects on Fertility: male index, itt-rat TDLo=400 mg/kg; post- implantation mortality, ims-mouse TDLo=259 mg/kg. Paternal Effects: spermatogenesis, Neurotoxicity: No information available. orl-rat TDLo=200 mg/kg; testes/sperm duct/epididymis, ipr-rat TDLo=80 mg/kg. Mutagenicity: Formaldehyde DNA Damage: human fibroblast 100 umol/L DNA Inhibition: human cell types 210 umol/L. Unscheduled DNA Synthesis: rat cell types 50 umol/L. Gene Other Studies: No data available. Mutation in Mammalian Cells: human lymphocyte 130 umol/L. https://fscimage.fishersci.com/msds/41129.htm 4/18/01#

Page 20Section 12 - Ecological Information Ecotoxicity: Atlantic salmon LC50=173 uL/L/96H; Catfish (fresh water) TLm=32ppm/24H; Flounder (salt water) TLm=100-330 ppm/48H; Fathead minnowLC50=10-100 uL/L/96H; Rainbow trout LC50= 168mg/L/48H; Zebrafish LC50=41mg/L/96H; Water flea LC50=52 (96Hr.) fathead minnow = 24.1 mg/L; flowthrough conditions; LC50 (96Hr.) bluegill = 0.10 mg/L/24H.Cas# 50-00-0: LC50(96Hr.) rainbow trout = 0.12 mL/L; flowthrough bioassay; LC50 photobacterium phospherum = 3.00-10.2 mg/L; Microtox. mg/L; Flow-through conditions;EC50 (96Hr.) water flea = 20 mg/L; EC50 (30 min) Environmental Fate: No information found. Physical/Chemical: No information found. Other: Not available. Section 13 - Disposal Considerations nazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Chemical waste generators must determine whether a discarded chemical is classified as a regulations to ensure complete and accurate classification. Parts 261.3. Additionally, waste generators must consult state and local hazardous waste RCRA P-Series: None listed. RCRA U-Series: CAS# 50-00-0: waste number U122. CAS# 67-56-1: waste number U154; (Ignitable waste). Section 14 - Transport Information US DOT IATA RID/ADR IMO Canada TDG AVIATION Shipping Name: LIQUID,N.O.S. REGULATED No FORMALIN) (10% information available. Hazard Class: 9 UN Number: UN3334 Päcking Group! Section 15 - Regulatory Information US FEDERAL TSCA CAS# 50-00-0 is listed on the TSCA inventory. CAS# 67-56-1 is listed on the TSCA inventory. CAS# 127-09-3 is listed on the TSCA inventory. CAS# 7732-18-5 is listed on the TSCA inventory. None of the chemicals are on the Health & Safety Reporting List. Health & Safety Reporting List https://fscimage.fishersci.com/msds/41129.htm 4/18/01#

Page 21Laguvul l Chemical Test Rules None of the chemicals in this product are under a Chemical Test Rule. Section 12b None of the chemicals are listed under TSCA Section 12b. TSCA Significant New Use Rule SARA None of the chemicals in this material have a SNUR under TSCA. Section 302 (RQ) CAS# 50-00-0: final RQ = 100 pounds (45.4 kg) CAS# 67-56-1: final RQ = 5000 pounds (2270 kg) Section 302 (TPQ) CAS# 50-00-0: TPQ = 500 pounds; RQ = 100 pounds (does not meet toxici ty criteria but SARA Codes because of high production volume and recognized toxic ity is considered a chemical of concern) CAS # 50-00-0: acute, chronic. CAS # 67-56-1: acute, flammable. Section 313 This material contains Formaldehyde (CAS# 50-00-0, 3 9 4 0%), which is subject to the reporting requirements of Section 313 of SARA Title III and 40 CFR Part 373. This material Section 313 of SARA Title III and 40 CFR Part 373. contains Methyl Alcohol (CAS# 67-56-1, 2 0%),which is subject to the reporting requirements of Clean Air Act: CAS# 50-00-0 is listed as a hazardous air pollutant (HAP). CAS# 67-56-1 is listed as a hazardous air pollutant (HAP). This material does not contain any Class 1 Ozone depletors. This Clean Water Act: material does not contain any Class 2 Ozone depletors. CAS# 50-00-0 is listed as a Hazardous Substance under the CWA. None of the chemicals in this listed as Toxic Pollutants under the CWA. product are listed as Priority Pollutants under the CWA. None of the chemicals in this product are OSHA: CAS# 50-00-0 is considered highly hazardous by OSHA. STATE Florida, Pennsylvania, Minnesota, Massachusetts. CAS# 50-00-0 can be found on the following state right to know lists: California, New Jersey, CAS# 67-56-1 can be found on the following state right to know lists: California, New Jersey, Florida, Pennsylvania, Minnesota, Massachusetts. CAS# 7732-18-5 is not present on state lists from CA, PA, MN, MA, FL, or NJ. CAS# 127=09-3. is not present on. state lists from CA, PA, MN, MA, FL, or NJ. The following statement(s) is(are) made in order to comply with the California Safe state of California to cause cancer. California No Significant Risk Level: CAS# 50-00-0: no Drinking Water Act: WARNING: This product contains Formaldehyde, a chemical known to the significant risk level = 40 ug/day European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: Risk Phrases: Not available. Safety Phrases: WGK (Water Danger/Protection) CAS# 50-00-0: 2 CAS# 67-56-1: 1 CAS# 127-09-3: 1 CAS# 7732-18-5: No information available. Canada CAS# 50-00-0 is listed on Canada's DSL/NDSL List. https://fscimage.fishersci.com/msds/41129.htm 4/18/01#

Page 22rage / OI / CAS# 67-56-1 is listed on Canada's DSL/NDSL List. CAS# 127-09-3 is listed on Canada's DSL/NDSL List. CAS# 7732-18-5 is listed on Canada's DSL/NDSL List. This product has a WHMIS classification of D1B, D2A. CAS# 50-00-0 is not listed on Canada's Ingredient Disclosure List. CAS# 67-56-1 is not listed on Canada's Ingredient Disclosure List. CAS# 127-09-3 is not listed on Canada's Ingredient Disclosure List. Exposure Limits CAS# 7732-18-5 is not listed on Canada's Ingredient Disclosure List. STRALIA:TWA 1 ppm (1,5 mg/m3);STEL 2 ppm (3 mg/m3);CAR OEL-BELGIUM:TW CAS# 50-00-0: OEL-ARAB Republic of Egypt:TWA 2 ppm (3 mg/m3) OEL-AU A 1 ppm (1.2 mg/m3);STEL 2 ppm (2.5 mg/m3); CAR OEL-CZECHOSLOVAKIA:TWA 0.5 mg/m3;STEL 1 mg/m3 OEL-DENMARK:STEL 0.3 ppm (0.4 mg/m3); Carcinog en OEL-FINLAND:STEL 1 ppm (1.3 mg/m3); Skin OEL-FRANCE:STEL 2 ppm (3 mg/m3) OEL-GERMANY:TWA 0.5 ppm (0.6 mg/m3); Carcinogen OEL-HUNGARY:ST EL 0.6 mg/m3;Carcinogen OEL-JAPAN: TWA 0.5 ppm (0.61 mg/m3);Carcinogen THE PHILIPPINES: TWA 5 ppm (6 mg/m3) OEL-POLAND:TWA 2 mg/m3 OEL-RUSSI DEL-IHE NETHERLANDS:TWA 1 ppm (1.5 mg/m3);STEL 2 ppm (3 mg/m3) OEL- A:TWA 0.5 ppm;STEL 0.5 mg/m3;Skin OEL-SWEDEN: TWA 0.5 ppm (0.6 mg/m3); STEL 1 ppm (1. mg/m3) OEL-SWITZERLAND:TWA 0.5 ppm (0.6 mg/m3);STEL 1 PP (1.2 mg/m3) OEL-THAILAND: TWA 3 ppm;STEL 5 ppm OEL-TURKEY: TWA 5 pp m (6 mg/m3) OEL-UNITED KINGDOM:TWA 2 ppm (2.5 mg/m3);STEL 2 ppm (2.5 IN NEW ZELAND, SINGAPORE, VIETNAM check ACGI TLV mg/m3) OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL CAS# 67-56-1: OEL-ARAB Republic of Egypt: TWA 200 ppm (260 mg/m3);Ski n OEL-AUSTRALIA: TWA 200 ppm (260 mg/m3);STEL 250 ppm;Skin OEL-BELGIU M: TWA 200 ppm (262 mg/m3);STEL 250 ppm;Skin OEL-CZECHOSLOVAKIA:TWA 10 0 mg/m3;STEL 500 mg/m3 OEL-DENMARK: TWA 200 ppm (260 mg/m3); Skin OEL- FINLAND: TWA 200 ppm (260 mg/m3);STEL 250 ppm;Skin OEL-FRANCE:TWA 200 ppm (260 mg/m3);STEL 1000 ppm (1300 mg/m3) OEL-GERMANY:TWA 200 ppm (2 -JAPAN: TWA 200 ppm (260 mg/m3);Skin OEL-THE NETHERLANDS: TWA 200 ppm ( 60 mg/m3);Skin OEL-HUNGARY:TWA 50 mg/m3;STEL 100 mg/m3;Skin JAN9 OEL 260 mg/m3);Skin OEL-THE PHILIPPINES:TWA 200 ppm (260 mg/m3) OEL-POLA ND: TWA 100 mg/m3 OEL-RUSSIA:TWA 200 ppm;STEL 5 mg/m3;Skin OEL-SWEDEN :TWA 200 ppm (250 mg/m3);STEL 250 ppm (350 mg/m3);Skin OEL-SWITZERLAN D: TWA 200 ppm (260 mg/m3);STEL 400 ppm;Skin OEL-THAILAND: TWA 200 ppm (260 mg/m3) OEL-TURKEY:TWA 200 ppm (260 mg/m3) OEL-UNITED KINGDOM:TW RDAN, KOREA check ACGIH TLV OEL IN NEW ZELAND, SINGAPORE, VIETNAM ch A 200 ppm (260 mg/m3); STEL 250 ppm;Skin OEL IN BULGARIA, COLOMBIA, JO eck ACGI TLV Section 16 - Additional Information MSDS Creation Date: 7/12/1999 Revision #3 Date: 8/02/2000 https://fscimage.fishersci.com/msds/41129.htm 4/18/01#

Page 23• Material Safety Data Sheet Formalin Neutral Buffered 10% w/v ACC# 41127 Section 1 - Chemical Product and Company Identification MSDS Name: Formalin Neutral Buffered 10% w/v Catalog Numbers: SF100 20, SF100 200, SF100 4, SF10020, SF100200, SF1004 Synonyms: None company Identification: Fisher Scientific 1 Reagent Lane For information, call: 201-796-7100 Fair Lawn, NJ 07410 Emergency Number: 201-796-7100 For International CHEMTREC assistance, call: 703-527-3887 For CHEMTREC assistance, call: 800-424-9300 Section 2 - Composition, Information on Ingredients CAS# Chemical Name Percent 50-00-0 / EINECS/ELINCS Formaldehyde 4.0 200-001-8 67-56-1 Methyl alcohol 1.0-2.0 200-659-6 7558-79-4 Sodium phosphate dibasic 0.65 231-448-7 7732-18-5 Water 10049-21-5 91.9-92. 231-791-2 Sodium phosphate, Monobasic, Monohydrate 0.4 unlisted Section 3 - Hazards Identification EMERGENCY OVERVIEW Appearance: clear. Danger! May cause allergic skin reaction. This substance has caused •..adverse reproductive. and fetal effects. in animals. May cause centraL nervous system depression. formaldehye. Respiratory sensitizer. Potential cancer hazard. Causes eye and skin irritation. Causes digestive and respiratory tract irritation. Contains Target Organs: Central nervous system. Potential Health Effects Eye: Causes eye irritation. Contact may cause ulceration of the conjunctiva and cornea. Skin: Causes skin irritation. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material. Ingestion: Causes gastrointestinal irritation with nausea, vomiting and diarrhea. May cause dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, central nervous system depression, characterized by excitement, followed by headache, coma and possible death due to respiratory failure. May cause systemic toxicity including central nervous system depression, convulsions, coma, and possible death due to respiratory failure. https://fscimage.fishersci.com/msds/41127.htm 4/18/01#

Page 24- Inhalation: May cause asthmatic attacks due to allergic sensitization of the respiratory tract. Chronic: Formaldehyde has been associated with nasal and nasopharyngeal cancers. Repeated exposure may cause skin discoloration and thickening and nail decay. Section 4 - First Aid Measures Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Do NOT allow victim to rub or keep eyes closed. Skin: Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Wash clothing before reuse. Destroy contaminated shoes. Ingestion: Do NOT induce vomiting. If victim is conscious and alert, give. 2-4 cupfuls of milk or Inhalation: Get medical aid immediately. Remove from exposure to fresh air immediately. If water. Never give anything by mouth to an unconscious person. Get medical aid immediately. breathing is difficult, give oxygen. DO NOT use mouth-to-mouth respiration. If breathing has and a mask. ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag Notes to Physician: Treat symptomatically and supportively. Section 5 - Firefighting Measures demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating General Information: As in any fire, wear a self-contained breathing apparatus in pressure- and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. Containers may explode when heated. resistant foam. For large fires, use dry chemical, carbon dioxide, alcohol-resistant foam, or Extinguishing Media: For small fires, use dry chemical, carbon dioxide, water spray or alcohol- water spray. Cool containers with flooding quantities of water until well after fire is out. Section 6 - Accidental Release Measures General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Remove all sources of ignition. Absorb spill using an absorbent, non-combustible be used to reduce vapors. Water spray may reduce vapor but may not prevent ignition in closed material such as earth, sana, or vermiculite. Provide ventilation. A vapor suppressing foam may spaces. --- Section 7 - Handling and Storage Handling: Wash thoroughly after handling. Use only in a well-ventilated area. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. , Do not ingest or inhale. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Storage: Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in https://fscimage.fishersci.com/msds/41127.htm 4/18/01#

Page 25• a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Section 8 - Exposure Controls, Personal Protection yewash facility and a safety shower. Use adequate general or local exhaust ventilation to kee engineering controls: Facilities storing or utilizing this material should be equipped with ar airborne concentrations below the permissible exposure limits. Chemical Name ACGIH NIOSH OSHA - Final PELs 0.016 ppm TWA; NIOSH Formaldehyde C 0.3 ppm Potential Occupational Appendix A Potential Carcinogen - see opm STEL; 0.5 ppm TWA 0.75 ppm TWA PEL; 2 NIOSH carcinogen. action leve Methyl alcohol 1200 ppm; 250 ppm STEL; skin - potential for mg/m3 TWA 6000 ppm 200 ppm TWA; 260 200 ppm TWA; 260 Sodium phosphate dibasic none listed cutaneous absorption IDLH mg/m3 TWA Water none listed none listed none listed Sodium phosphate, none listed none listed Monobasic, Monohydrate none listed none listed none listed OSHA Vacated PELs: Formaldehyde: 3 ppm TWA (unless specified in 1910.1048) Methyl alcohol: 200 ppm TWA; 260 mg/m3 TWA Sodium phosphate dibasic: No OSHA Vacated PELs are listed for this chemical. Water: No OSHA Vacated PELs are listed for this chemical. Sodium phosphate, Monobasic, Monohydrate: No OSHA Vacated PELs are listed for this chemical. Personal Protective Equipment OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary. Section 9 - Physical and Chemical Properties Physical State: Liquid Appearance: clear - • Odor: strong odor - pungent odor pH: 6.9-7.1 Vapor Pressure: Not available. Vapor Density: 1.0 Viscosity: Not available. Evaporation Rate:>1.0 Boiling Point: 201-212 deg F Freezing/Melting Point:32 deg F Decomposition Temperature:Not available. Flash Point: Not applicable. Autoignition Temperature: Not applicable. https://fscimage.fishersci.com/msds/41127.htm 4/18/01#

Page 26• u. Explosion Limits, Lower:7.0% NFPA Rating: Not published. Upper: Not available. Solubility: Soluble in water. Specific Gravity/Density:1.10 Molecular Formula:Mixture Molecular Weight:Not available. Section 10 - Stability and Reactivity Chemical Stability: Stable under normal temperatures and pressures. dioxide, formaldehyde. Hazardous Polymerization: Has not been reported. Section 11 - Toxicological Information RTECS#: CAS# 50-00-0: LP8925000 CAS# 67-56-1: PC1400000 CAS# 7732-18-5: ZC0110000 CAS# 7558-79-4: WC4500000 CAS# 10049-21-5 unlisted. LD50/LC50: CAS# 50-00-0: Inhalation, mouse: LC50 =400 mg/m3/2H; Inhalation, rat: LC50 =203 mg/m3; Oral, rat: LD50 = 100 mg/kg; Oral, mouse: LD50 = 42 mg/kg; Skin, rabbit: LD50 = 270 mg/kg; • CAS# 67-56-1: Inhalation, rat: LC50 =64000 ppm/4H; Oral, mouse: LD50 = 7300 mg/kg; Oral, rabbit: LD50 = 14200 mg/kg; Oral, rat: LD50 = 5628 mg/kg; Skin, rabbit: LD50 = 15800 mg/kg; CAS# 7558-79-4: Oral, rat: LD50 = 17 gm/kg; CAS# 7732-18-5: CAS# 10049-21-5: Oral, rat: LD50 = >90 mL/kg; CAS# 50-00-0: Carcinogenicity: ACGIH: A2 - suspected human carcinogen California: carcinogen; initial date 1/1/88 NIOSH: occupational carcinogen https://fscimage.fishersci.com/msds/41127.htm 4/18/01#

Page 27OSHA: Possible Select carcinogen NTP: Suspect carcinogen CAS# 7558-79-4: Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA. CAS# 7732-18-5: Not TARC: Group 2A carcinogen CAS# 67-56-1: Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA. listed by ACGIH, IARC, NIOSH, NTP, or OSHA. CAS# 10049-21-5: Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA. Epidemiology: Formaldehyde has been shown to increase the incidence of lu ng cancer in workers. In another study, there was increase i n mortality from lung cancer when workers were exposed to conc. over 2 ppm of formaldehyde. Teratogenicity: Formaldehyde effects on Newborn: behavioral, ihl-rat TCLo=50 ug/m3/4H; biochemical/metabolic and reduced weight gain, ihl-rat TCLo=12 ug/m3/24H. Embryo or Fetus: cytological changes, ihi-rat TCLo=1mg/m3/24H; stunted fetus and death, ipr-mouse TDLo=240 TDLo=240 mg/kg. mg/kg. Specific Developmental Abnormalities: craniofacial and musculoskeletal, ipr-mouse Reproductive Effects: Formaldehyde effects on Fertility: male index, itt-rat TDLo=400 mg/kg; orl-rat TDLo=200 mg/kg; testes/sperm duct/epididymis, ipr-rat TDLo=80 mg/kg. post- implantation mortality, ims-mouse TDLo=259 mg/kg. Paternal Effects: spermatogenesis, Neurotoxicity: No information available. Mutagenicity: Formaldehyde DNA Damage: human fibroblast 100 umol/L DNA Inhibition: human cell types 210 umol/L; Unscheduled DNA Synthesis: rat cell types 50 umol/L; Gene Other Studies: See actual entry in RECS for complete information. Mutation in Mammalian Cells: human lymphocyte 130 umol/L. Section 12 - Ecological Information Ecotoxicity: Atlantic salmon LC50=173 uL/L/96H; Catfish (fresh water)TLm=32 ppm/24H;Flounder (salt water) TLm=100-330 ppm/48H; Fathead minnowLC50=10-100 uL/L/96H; Rainbow trout LC50= 168mg/L/48H;Zebrafish LC50=41mg/L/96H; Water flea LC50=52 mg/L/24H. LC50(96Hr.) rainbow trout = 0.12 mL/L; flowthrough bioassay; LC50 (96Hr.) fathead minnow = 24.1 mg/L; flowthrough conditions;LC50 (96Hr.) bluegill = 0.10 mg/L; Flow-through conditions; EC50 (96Hr.) water flea = 20 mg/L; EC50 (30 min) Environmental Fate: No information found. photobacterium phospherum = 3.00-10.2 mg/L; Microtox. Physical/Chemical: No information found. Other: Not available. Section 13 - Disposal Considerations Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR regulations to ensure complete and accurate classification. Parts 261.3. Additionally, waste generators must consult state and local hazardous waste RCRA P-Series: None listed. (Ignitable waste). RCRA U-Series: CAS# 50-00-0: waste number U122. CAS# 67-56-1: waste number U154; Section 14 - Transport Information 4-... https://fscimage.fishersci.com/msds/41127.htm 4/18/01#

Page 28US DOT IATA RID/ADR IMO AVIATION Canada TDG Shipping Name: LIQUID,N.O.S. REGULATED FORMALDEHYDE FORMALIN) (10% SOLUTIONS Hazard Class: UN Number: UN3334 3(8) (9.2). UN1198 Packing Group: III Section 15 - Regulatory Information US FEDERAL - TSCA CAS# 50-00-0 is listed on the TSCA inventory. CAS# 67-56-1 is listed on the TSCA inventory. CAS# 7558-79-4 is listed on the TSCA inventory. CAS# 7732-18-5 is listed on the TSCA inventory. Inventory requirements (40CFR720.3(u) (2)). CAS# 10049-21-5 is not on the TSCA Inventory. It is a hydrate and exempt from TSCA Health & Safety Reporting List None of the chemicals are on the Health & Safety Reporting List. Chemical Test Rules None of the chemicals in this product are under a Chemical Test Rule. Section 12b None of the chemicals are listed under TSCA Section 12b. TSCA Significant New Use Rule None of the chemicals in this material have a SNUR under TSCA. SARA Section 302 (RQ) CAS# 50-00-0: final RQ = 100 pounds (45.4 kg) CAS# 67-56-1: final RQ = 5000 pounds (2270 Section 302 (TPQ) kg) CAS# 7558-79-4: final RQ = 5000 pounds (2270 kg) CAS# 50-00-0: TPQ = 500 pounds; RQ = 100 pounds (does not meet toxici ty criteria but •"because of high production volume and recognized toxic ity is considered a chemical of concern SARA Codes • Section 313•• CAS # 50-00-0: acute, chronic. CAS # 67-56-1: acute, flammable. .•... .... This material contains Formaldehyde (CAS# 50-00-0, 4 0%), which is subject to the reporting requirements of Section 313 of SARA Title III and 40 CFR Part 373. This material contains Section 313 of SARA Title III and 40 CFR Part 373. Methyl alcohol (CAS# 67-56-1, 1 0 2 0%), which is subject to the reporting requirements of Clean Air Act: CAS# 50-00-0 is listed as a hazardous air pollutant (HAP). CAS# 67-56-1 is listed as a hazardous air pollutant (HAP). This material does not contain any Class 1 Ozone depletors. This Clean Water Act: material does not contain any Class 2 Ozone depletors. CAS# 50-00-0 is listed as a Hazardous Substance under the CWA. CAS# 7558-79-4 is listed as a Hazardous Substance under the CWA. None of the chemicals in this product are listed as -Pollutants under the WA:--. Priority Pollutants under the CWA. None of the chemicals in this product are listed as Toxic OSHA: https://fscimage.fishersci.com/msds/41127.htm 4/18/01#

Page 29euge i ve u STATE CAS# 50-00-0 is considered highly hazardous by OSHA. CAS# 50-00-0 can be found on the following state right to know lists: California, New Jersey, Florida, Pennsylvania, Minnesota, Massachusetts. Florida, Pennsylvania, Minnesota, Massachusetts. CAS# 67-56-1 can be found on the following state right to know lists: California, New Jersey, CAS# 7558-79-4 can be found on the following state right to know lists: California, New Jersey, Pennsylvania, Massachusetts. CAS# 7732-18-5 is not present on state lists from CA, PA, MN, MA, FL, or NJ. CAS# 10049-21-5 is not present on state lists from CA, PA, MN, MA, FL, or NJ. The following statements) is (are) made in order to comply with the California Safe state of California to cause cancer. California No Significant Risk Level: CAS# 50-00-0: no Drinking Water Act: WARNING: This product contains Formaldehyde, a chemical known to the significant risk level = 40 ug/day European/International Regulations Hazard Symbols: European Labeling in Accordance with EC Directives Not available. Risk Phrases: Safety Phrases: WGK (Water Danger/Protection) CAS# 50-00-0: 2 CAS# 67-56-1: 1 CAS# 7558-79-4: 1 CAS# 7732-18-5: No information available. CAS# 10049-21-5: 1 Canada CAS# 50-00-0 is listed on Canada's DSL/NDSL List. CAS# 67-56-1 is listed on Canada's DSL/NDSL List. CAS# 7732-18-5 is listed on Canada's DSL/NDSL List. CAS# 7558-79-4 is listed on Canada's DSL/NDSL List. This product has a WHMIS classification of D1B, D2A. CAS# 50-00-0 is not listed on Canada's Ingredient Disclosure List. CAS# 7558-79-4 is not listed on Canada's Ingredient Disclosure List. CAS# 67-56-1 is not listed on Canada's Ingredient Disclosure List. CAS# 10049-21-5 is not listed on Canada's Ingredient Disclosure List. CAS# 7732-18-5 is not listed on Canada's Ingredient Disclosure List. Exposure Limits CAS# 50-00-0: OEL-ARAB Republic of Egypt: TWA 2 ppm (3 mg/m3) OEL-AU A 1 ppm (1.2 mg/m3);STEL 2 ppm (2.5 mg/m3); CAR OEL-CZECHOSLOVAKIA: TWA STRALIA: TWA 1 ppm (1.5 mg/m3);STEL 2 ppm (3 mg/m3);CAR OEL-BELGIUM:TW 0.5 mg/m3;STEL 1 mg/m3 OEL-DENMARK:STEL 0.3 ppm (0.4 mg/m3);Carcinog en DEL-FINLAND:STEL 1 ppm (1.3 mg/m3);Skin OEL-FRANCE:STEL 2 ppm (3 mg/m3) OEL-GERMANY:TWA 0.5 ppm (0.6 mg/m3);Carcinogen OEL-HUNGARY:ST EL 0.6 mg/m3;Carcinogen OEL-JAPAN: TWA 0.5 ppm (0.61 mg/m3); Carcinogen OEL-THE NETHERLANDS:TWA 1 ppm (1.5 mg/m3);STEL 2 ppm (3 mg/m3) OEL- THE PHILIPPINES: TWA 5 ppm (6 mg/m3) OEL-POLAND: TWA 2 mg/m3 OEL-RUSSI A:TWA 0.5 ppm;STEL 0.5 mg/m3;Skin OEL-SWEDEN: TWA 0.5 ppm (0.6 mg/m3); STEL 1 ppm (1. mg/m3) OEL-SWITZERLAND:TWA 0.5 ppm (0.6 mg/m3);STEL 1 PP (1.2 mg/m3) OEL-THAILAND:TWA 3 ppm;STEL 5 ppm OEL-TURKEY: TWA 5 pp m (6 mg/m3) OEL-UNITED KINGDOM: TWA 2 ppm (2.5 mg/m3);STEL 2 ppm (2.5 IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGI TLV mg/m3) DEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL CAS# 67-56-1: OEL-ARAB Republic of Egypt:TWA 200 ppm (260 mg/m3);Ski https://fscimage.fishersci.com/msds/41127.htm 4/18/01#

Page 30rage o ul o n OEL-AUSTRALIA:TWA 200 ppm (260 mg/m3);STEL 250 ppm;Skin OEL-BELGIU 0 mg/m3;STEL 500 mg/m3 OEL-DENMARK:TWA 200 ppm (260 mg/m3);Skin OEL- M: TWA 200 ppm (262 mg/m3) ;STEL 250 ppm;Skin OEL-CZECHOSLOVAKIA:TWA 10 FINLAND:TWA 200 ppm (260 mg/m3); STEL 250 ppm;Skin OEL-FRANCE: TWA 200 60 mg/m3);Skin OEL-HUNGARY:TWA 50 mg/m3;STEL 100 mg/m3; Skin JAN9 OEL ppm (260 mg/m3);STEL 1000 ppm (1300 mg/m3) OEL-GERMANY: TWA 200 ppm (2 -JAPAN: TWA 200 ppm (260 mg/m3);Skin OEL-THE NETHERLANDS: TWA 200 ppm ( 260 mg/m3);Skin OEL-THE PHILIPPINES: TWA 200 ppm (260 mg/m3) OEL-POLA ND: TWA 100 mg/m3 OEL-RUSSIA:TWA 200 ppm;STEL 5 mg/m3;Skin OEL-SWEDEN :TWA 200 ppm (250 mg/m3);STEL 250 ppm (350 mg/m3);Skin OEL-SWITZERLAN D:TWA 200 ppm (260 mg/m3);STEL 400 ppm;Skin OEL-THAILAND:TWA 200 ppm (260 mg/m3) OEL-TURKEY:TWA 200 ppm (260 mg/m3) OEL-UNITED KINGDOM:TW A 200 ppm (260 mg/m3);STEL 250 ppm;Skin OEL IN BULGARIA, COLOMBIA, JO RDAN, KOREA check ACGIH TLV OEL IN NEW ZELAND, SINGAPORE, VIETNAM ch eck AGI TLV Section 16 - Additional Information MSDS Creation Date: 7/12/1999 Revision #4 Date: 8/02/2000 https://fscimage.fishersci.com/msds/41127.htm 4/18/01#

Page 31r. MATERIAL SAFET DATA SHEET SECTION I CHEMICAL PRODUCT AND COMPANY IDENTIFICATION MANUFACTURER: BDH INC. - 800387-1035 4166269555Sayen@UWk 350 EVANS AVENUE HOURS: MON. TO FRI. INFORMATION PHONE Nº(0830 416-255-8521 TORONTO, ONTARIO 1 - 16301 CANADA, M8Z 1K5 CHEMTREC TRANSPORTATION EMERGENCY CENTER PRODUCT NAME: BUFFERED NEUTRAL FORMALIN 10%, FORMALDERYDE 10%, BUFFERED (CHEMTREC) 24-AOUR.,• .1-800-424-9300 NEUTRAL 23% CATALOGUE NUMBERS): VW3239, VW3323, VW5801 THE PRODUCI FORMALDEHYDE 10%, WHILE VW3239 DOES CONTAIN PHOSPHATES PRODUCT #VW3323 DOES NOT CONTAIN ANY PHOSPHATES CHEMICAL NAME/OTHER NAME: BUFFERED NEUTRAL FORMALIN 10%; FORMALDEHYDE 10%, 23% CHEMICAL FORMULA: H20, HCHO, NAZHP04, NAH2P04. H20 CHEMICAL FAMILY: MIXTURE SECTION II COMPOSITION/INFORMATION ON INGREDIENTS CHEMICAL NAME CAS NO. OSHA PEL ACGIH TLV % (W/V) FORMALDEHYDE 10049-21-5 7558-79-4 50-00-0 0.3 PPM 0.3 PPM WATER SODIUM PHOSPHATE SODIUM PHOSPHATE - 0.65 4-9 7732-18-5 0.4 SECTION III HAZARDS IDENTIFICATION APPEARANCE: CLEAR, COLORLESS LIQUID ********* ******************** EMERGENCY OVERVIEW ********************** ***** * CONTAINS MATERIAL (FORMALDEHYDE) WHICH MAY CAUSE CANCER * IRRITATING TO THE SKIN, EYES AND MUCOUS MEMBRANES * * HARMFUL IF INHALED, SWALLOWED OR ABSORBED THROUGH SKIN * ***: ********** **************** (REFER TO LAST PAGE FOR DISCLAIMER) : VW3239 PAGE: 1 : : : :#

Page 32POTENTIAL HEALTH EFFECTS (ACUTE & CHRONIC) SYMPTOMS_OF EXPOSURE: VAPOR IS IRRITATING TO THE EYES AND TISSUES OF THE MEDICAL CONDITION AGGRAVATED BY EXPOSURE: RESPIRATORY CONDITIONS RESPIRATORY TRACT, EYE CONTACT MAY RESULT IN DAMAGE: CARCINOGENICITY: FORMALDEHYDE IS LISTEO AS A CARCINUGEN (IARC) ROUTES OF ENTRY: INHALATION, INGESTION SECTION IV FIRST AID MEASURES 15 EYE: IN CASE OF EYE CONTACT, FLUSH WITH PLENTY OF WATER FOR AT LEAST MINUTES WHILE HOLDING THE EYELIDS OPEN, HAVE EYES EXAMINED BY MEDICAL PERSONNEL. SKIN: IN_CASE OF SKIN CONTACT, .. WATER FOR AT. LEAST 15 MINUTES WHILE REMOVING CONTAMINATED IMMEDIATELY FLUSH SKIN WITH PLENTY OF CLOTHING AND SHOES. INGESTION: IF SWALLOWED, DO NOT INDUCE VOMITING. GIVE VICTIM A GLASS OF BY MOUTH OR MILK. CALL A PHYSICIAN IMMEDIATELY. NEVER GIVE ANYTHING TO AN UNCONSCIOUS PERSON. INHALATION: IF INHALED, PERSONNEL SHOULD BEGIN ARTIFICIAL RESPIRATION. SEEK MEDICAL REMOVE TO FRESH AIR. IF NOT BREATHING, TRAINED ATTENTION. SECTION V FIRE FIGHTING MEASURES FLAMMABILITY CLASSIFICATION: NONCOMBUSTIBLE FLASH POINT (F) /METHOD: NOT AVAILABLE EXTINGUISHING MEDIA: CARBON DIOXIDE, FOAM OR WATER SPRAY FIRE & EXPLOSION HAZARD: MAY EMIT TOXIC FUMES ON THERMAL DECOMPOSITION. UPPER FLAMMABLE LIMIT (%]: NOT AVAILABLE AUTOIGNITLON TEMPERATURE: NOT AVAILABLE LOWER FLAMMABLE LIMIT (%): NOT AVAILABLE APPARATUS. FIREFIGHTING PROCEDURES: FIREFIGHTERS SHOULD WEAR A SELF CONTAINED BREATHING SENSITIVITY TO MECHANICAL IMPACT: NO SENSITIVITY TO STATIC DISCHARGE: NO ••----- SECTION VI ACCIDENTAL RELEASE MEASURES LEAK OR SPILL CLEANUP: EVACUATE THE AREA OF ALL UNNECESSARY PERSONNEL. WEAR (REFER TO LAST PAGE FOR DISCLAIMER) VW3239 PAGE: 2#

Page 33SUITABLE PROTECTIVE EQUIPMENT LISTED_ IN EXPOSURE_CONTROLS/PERSONAL PROTECTION. RISK. TAKE UP AND CONTAINERIZE FOR _PROPER DISPOSAL AS DESCRIBED UNDER CONTAIN THE RELEASE AND ELIMINATE IT'S SOURCE, IF THIS CAN BE DONE WITHOUT RELEASES. DISPOSAL, COMPLY WITH FEDERAL, REFER TO REGULATORY INFORMATION FOR REPORTABLE QUANTITY AND OTHER STATE, AND LOCAL REGULATIONS ON REPORTING REGULATORY DATA. SECTION VII HANDLING & STORAGE MANOLING & SURAGE KEEP CONTAINER TIGHTLY CLOSED. SPARKS AND OPEN FLAME. DO NOT BREATHE VAPOR OR MIST TORE AWAY FROM HEAT, SECTION VIII EXPOSURE CONTROLS/PERSONAU PROTECTION IMPLEMENTED TO REDUCE EXPOSURE. ENGINEERING CONTROLS: ENGINEERING AND/OR AOMINISTRATIVE CONTROLS SHOULD BE PERSONAL PROTECTIVE EQUIPMENT GLOVES: NEOPRENE, NITRILE OR EQUIVALENT RESPIRATORY PROTECTION: FUME HOOD OR NIOSH/MSHA RESPIRATORS AS APPROPRIATE CLOTHING: IMPERVIOUS PROTECTIVE CLOTHING SHOULD BE WORN TO PREVENT SKIN *Y* PRULECTION: SAFETY GLASSES WITH SIDE SHIELDS CONTACT. SECTION IX PHYSICAL & CHEMICAL PROPERTIES PHYSICAL STATE: LIQUID ODOR: FORMALDEHYDE ODOR APPEARANCE: CLEAR, COLORLESS LIQUID VAPOR PRESSURE: NOT AVAILABLE ODOR THRESHOLD: NOT AVAILABLE VAPOR DENSITY: NOT AVAILABLE BOILING POINT (F): DECOMPOSES SPECIFIC GRAVITY: NOT AVAILABLE MELTING POINT (FI: NOT AVAILABLE EVAPORATION RATE: NOT AVAILABLE SOLUBILITY IN WATER: MISCIBLE PH: NOT AVAILABLE OCTANOL/WATER PARTITION COEFFICIENT: NOT AVAILABLE MOLECULAR WEIGHT: 30.03 (FORMALDEHYDE) PER CENT VOLATILE BY VOL (%): 100 SECTION X STABILITY & REACTIVITY (REFER TO LAST PAGE FOR DISCLAIMER) VW3239 PAGE: 3 :#

Page 34CHEMICAL STABILITY: NORMALLY STABLE CONDITIONS TO AVOID: CONTACT WITH IGNITION SOURCES MATERIALS TO AVOID: HYDROCHLORIC ACID FORMATION OF BISCHLOROMETHYL ETHER, A HAZARDOUS POLYMERIZATION: DOES NOT OCCUR POTENT CARCINOGEN) HAZARDOUS DECOMPOSITION PRODUCTS: COX SECTION XI TOXICOLOGICAL_ INFORMATION CONTACT WITH THE EYES MAY RESULT IN DAMAGE. EFFECTS OF ACUTE EXPOSURE: VAPOR IS IRRITATING TO THE EYES, NOSE AND THROAT. ASSOCIATED WITH CANCERS OF THE LUNGS AND RESPIRATORY PASSAGES. EFFECTS OF CHRONIC EXPOSURE: IN HUMANS, FORMALDEHYDE EXPOSURE HAS BEEN LC50: NOT AVAILABLE LD50: NOT AVAILABLE IRRITANCY. (DRAIZE TEST RESULTS): NO INFORMATION AVAILABLE TERATOGENICITY: NO INFORMATION AVAILABLE CARCINOGENICITY: FORMALDEHYDE IS LISTED AS A CARCINOGEN (IARC) MUTAGENICITY: MAY CAUSE ADVERSE MUTAGENIC EFFECTS (FORMALDEHYDE) SENSITIZATION TO PRODUCT: NO INFORMATION AVAILABLE SENSIT ZA YONE PRODUCT: NO I AVAILABLE YE EFFECTS "FORMALDEHYDE! TARGET ORGANS: NONE IDENTIFIED SECTION XII DISPOSAL CONSIDERATIONS EPA WASTE NUMBERISI: U122 TREATMENT: INCINERATION, PERMITTED WASTE DISPOSAL SITE (TSD) FOR PERMISSIBLE TREATMENT SITES. FUELS BLENDING OR RECYCLE. CONTACT YOUR LOCAL CURRENT LOCAL, STATE AND FEDERAL REGULATIONS ALWAYS CONTACT A PERMITTED WASTE DIPOSER ITSD) TO ASSURE COMPLIANCE WITH ALL SECTION XIII TRANSPORT INFORMATION FORMALDEHYDE) DOT SHIPPING NAME: ENVIRONMENTALLY HAZARDOUS SUBSTANCES, LIQUID, N.O.S. I PACKING GROUP: III DOT NUMBER (UN): 3082 HAZARD CLASS: 9.2 SECTION XIV REGULATORY INFORMATION TSCA INVENTORY (YES/NO1: YES, THIS MATERIAL IS A MIXTURE. THE CAS NUMBERS OF ALL COMPONENTS ARE LISTED ON THE TSCA INVENTORY. (REFER TO LAST PAGE FOR DISCLAIMER) VW3239 PAGE: 4#

Page 35COMPONENT SARA EHS (3021 SARA_EHS TO ALBS) CERCLA RD (LBS) WATER FORMALDEHYDE 500 100 - SODIUM PHOSPHATE - MONOBASIC DIBASIC SODIUM PHOSPHATE COMPONENT OSHA FLOOR LIST SARA 313 DEMINIMIS (SARA 313) 1% WATER FORMALDEHYDE Y 0.1 SODIUM PHOSPHATE MONOBASIC DIBASIC SODIUM PHOSPHATE - - - SECTION XV OTHER INFORMATION NFPA HAZARD RATINGS (0-4) HEALTH: 2 FLAMMABILITY: 1 REACTIVITY: 0 NFPA SPECIAL WARNINGS: NONE PREPARATION DATE: APRIL 6, 199: REVISION HISTORY: APRIL 6, 1993; MARCH 23, 1995 COMMENTS: NONE PREPARED BY: TECHNICAL AFFAIRS DEPARTMENT, BDH INC., TORDNTO, ONTARIO, CANADA (416) 255-8521| THE STATEMENTS CONTAINED HEREIN ARE OFFERED FOR INFORMATIONAL PURPOSES ONLY AND ARE BASED UPON TECHNICAL DATA THAT BDH INC BELIEVES TO BE ACCURATE. COPYRIGHT BDH, 1997 "ISSUED BY VWR 09-10-97" PAGE: 5 VW3239-1 RØ4586 :#

Page 36MATERIAL SAFET BDH_INC. DAT SHEET SECTION I PRODUCT IDENTIFICATION AND USE MANUFACTURER: BDH INC. 350 EVANS AVENUE 416-201-6393 (24 HR.) EMERGENCY TELEPHONE NO.: ONTARIO TORONTO 416-255-8521 (0830-1630) INFORMATION TELEPHONE NO.: M8Z 1K5 PRODUCT NAME: FORMALIN 10% OR BUFFERED NEUTRAL FORMALIN 10% PRODUCT CODETS): R04586, VH3239, FX0419 CHEMICAL FORMULA: HCHO, CHEMICAL NAME/OTHER NAME: FORMALIN 10%; FORMALDEHYOE SOLUTION 10% CHEMICAL FAMILY: MIXTURE IDG SHIPPING NAME/UN: NOT REGULATED TOG CLASSIFICATION/PACKING GROUP: NOT REGULATED USE: LABORATORY SECTION II HAZARDOUS INGREDIENTS CHEMICAL NAME CAS NO. LO50 % • METHANOL FORMALDEHYDE 50-00-0 1.5 67-56-1 800_ MG/KG(ORL, RAT) 5628 MG/KGIÖRL, RAT) SECTION III PHYSICAL DATA PHYSICAL STATE: LIQUID ODOUR APPEARANCE AND DDOUR: CLEAR, COLOURLESS LIBUID; SLIGHTLY PUNGENT HAY-LIKE ODOUR THRESHOLD: D.8 PPM (AS FORMALDEHYDE) VAPOUR PRESSURE: NOT AVAILABLE SPECIFIC GRAVITY: 1.01 VAPOUR DENSITY: NOT AVAILABLE EVAPORATION RATE: NOT AVAILABLE FREEZING POINT: NOT AVAILABLE BOILING POINT: NOT AVAILABLE PH: 7.0 1+/- 0.21 COEFFICIENT OF WATER/OIL DISTRIBUTION: NOT AVAILABLE SECTION IV FIRE OR EXPLOSION HAZARD --a4... CONDITIONS OF FLAMMABILITY: NONCOMBUSTIBLE FLASH POINT / METHOD: NOT AVAILABLE EXTINGUISHING MEDIA: DRY POWDER, CARBON DIOXIDE - TREFER TO LAST PAGE FOR DISCLAIMER) - RØ4586 PAGE: 1#

Page 37VEL: NOT AVAILABLE LEL: NOT AVAILABLE AUTOIGNITION TEMPERATURE: NOT AVAILABLE HAZARDOUS COMBUSTION PRODUCTS: COX, NA2D EXPLOSION DATA - SENSITIVITY TO MECHANICAL IMPACT: NO - SENSITIVITY TO STATIC DISCHARGE: NO SECTION V REACTIVITY DATA CONDITIONS OF INSTABILITY: NORMALLY STABLE INCOMPATIBILITIES: ACIDS, ALKALIES, ISOCYANATES, PHENOL, OXIDIZERS, GELATIN, BISULPRIDES, UREA, CONDITIONS OF REACTIVITY: TANNIN HAZARDOUS DECOMPOSITION PRODUCTS: COX, NORMALLY STABLE NA20 SECTION VI TOXICOLOGICAL PROPERTIES / HEALTH HAZARD DATA ROUTE OF ENTRY: -SKIN CONTACT: IRRITATES - SKIN ABSORPTION: NO INFORMATION AVAILABLE - INHALATION: IRRITATES - EYE CONTACT: IRRITATES LC50: NOT AVAILABLE -INGESTION: HARMFUL EXPOSURE LIMITS: ILV: 1 PPM (AS FORMALDEHYDE): 200 PPM (AS METHANOL) LD50: NOT AVAILABLE EFFECTS OF ACUTE EXPOSURE: CONTACT DF THIS SUBSTANDE WITH THE EYES OR SKIN FFECTS OF CHRONIC EXPOSURE: PROLONGED OR REPEATED SKIN CONTACT MAY RESULT II ESULT IN IRRITATION AND INGESTION MAY BE HARMFUL DERMATITIS. IRRITANCY: SENSITIZATION TO PRODUCT: NO INFORMATION AVAILABLE NO EXPERIMENTAL INFORMATION AVAILABLE REPRODUCTIVE TOXICITY MAY CAUSE REPRODUCTIVE ERECTS, REFERENCES CATED YELS* 345-389 (1982) (FORMALDEHYDE) LP8925000 (FORMALDEHYDE), RIECS*PC1400000 (METHANOL) PC1400000 (METHANOL) TERATOGENICILY: MAY CAUSE TERATOGENIC EFFECTS, REFBRENCES CITED:RTECS# MUTAGENICITY: MAY CAUSE MUTAGENIC EFFECTS, REFERENOES CITED: RTECS#PC1400000 TOXICOLOGICALLY SYNERGISTIC PRODUCTS: NONE FOUND (METHANOL) SECTION VII FIRST AID MEASURES ŚKIN" FÜÜSH THE CONTACT AREA WITH LUKEWARM RÜNNING WATER FOR AT LEAST 15 MINUTES. REMOVE CONTAMINATED CLOTHING, TAKING CARE NOT TO SPREAD THE CHEMICAL. • IREFER TO LAST PAGE FOR DISCLAIMER.) RØ4586 PAGE: 2 :#

Page 38IF CONTAMINATION IS EXTENSIVE, REMOVE CLOTHING UNDER RUNNING WATER. DISCARD DECONTAMINATE CLOTHING UNDER RUNNING WATER. DISCARD OR DECONTAMINATE CLOTHING MEDICAL ATTENTION IF IRRITATION PERSISTS. BEFORE USE. UNLESS CONTACI HAS BEEN SLIGHT, SEEK MEDICAL ATTENTION. SEEK RUNNING WATER, HOLDING THE EYELIDS OPEN, TAKE CARE NOT TO RINSE CONTAMINATED • INVOLVING THE EYES. WATER INTO THE NON-AFFECTED EYE. ALWAYS SEEK MEDICAL ATTENTION FOR ACCIDENTS INHALAL ON: TAKE PROPER PRECAUTIONS TO ENSURE YOUR OWN SAFETY BEFORE ATTEMPTING RESCUE. REMOVE SOURCE OF CONTAMINATION OR MOVE VICTIM TO FRESH AIR. IF BREATHING HAS STOPPED, TRAINED PERSONNEL SHOULD BEGIN ARTIFICIAL RESPIRATION, DR IF THE HEART HAS STOPPED, CARDIOPULMONARY RESUSCITATION (CPR) IMMEDIATELY. SEEK MEDICAL ATTENTION. CONSCIDUSNESS,_ OR IS UNCONSCIOUS OR CONVULSING. RINSE MOUTH THOROUGHLY WITH INGESTION:_NEVER GIVE ANYTHING BY MOUTH IF VICTIM IS RAPIDLY LOSING WATER. DO NOT INDUCE VOMITING. HAVE VICTIM DRINK 200-400 ML OF WATER TO DILUTE. IF BREATHING HAS STOPPED, TRAINED PERSONNEL SHOULD BEGIN ARTIFICIAL RESPIRATION, OR IF THE HEART HAS STOPPED, CARDIOPULMONARY RESUSCITATION (CPR) IMMEDIATELY. SEEK MEDICAL ATTENTION. SECTION VIII PREVENTIVE MEASURES ENGINEERING CONTROLS: ENGINEERING CONTROL METHODS TO REDUCE HAZARDOUS EXPOSURES ARE PREFERRED. METHODS INCLUDE MECHANICAL VENTILATION (DILUTION AND PROCESS OR PERSONNEL ENCLOSURE, , OF PROCESS CONDITIONS, AND PERSONAL PROTECTIVE EQUIPMENT: EQUIPMENT MAY ALSO BE REQUIRED. -GLOVES: PLASTIC -RESPIRATORY PROTECTION: FUMEHOOD AS APPROPRIATE -EYE PROTECTION: CHEMICAL SAFETY GOGGLES STORAGE REQUIREMENTS: STORE IN SUITABLE LABELLED CONTAINERS. KEEP CONTAINERS. -CLOTHING: PLASTIC APRON, SLEEVES AND BOOTS AS APPROPRIATE TIGHTLY CLOSED WHEN NOT IN USE AND WHEN EMPTY. PROTECT FROM DAMAGE.STORE IN A INCOMPATIBLE MATERIALS. COOL, DRY, WELL-VENTILATED AREA, OUT OF DIRECT SUNLIGHT. STORE AWAY FROM HANDLING PROCEDURES AND EQUIPMENT: AVOID BENERATING MIST. FOLLOW ROUTINE SAFE • FLAMMABLE MATERIALS, SHUT OFF ALL POSSIBLE SOURCES OF IGNITION. ABSORB ON INERT ABSORBENT, TRANSFER TO CONTAINER AND ARRANGE REMOVAL BY DISPOSAL COMPANY. (REFER TO LAST PAGE FOR DISCLAIMER) RØ4586 PAGE: 3 :#

Page 39• WASH SITE OF SPILLAGE THOROUGHLY WITH WATER AND DETERGENT. OR USE VYTAC FNC (FORMALDEHYDE NEUTRALIZING CONCENTRATE.. DISPOSAL: FOLLOW ALL FEDERAL, PROVINCIAL AND LOCAL REGULATIONS FOR DISPOSAL. USE ONLY LICENSED DISPOSAL AND WASTE HAULING COMPANIES. DISPOSAL OF SMALL AMOUNTS OF SPILLED MATERIAL MAY BE CLEANUP". LARGE SPILLS MUST BE DEALT WITH SEPARATELY AND MUST BE HANDLED BY HANDLED AS DESCRIBED UNDER "LEAK OR SPILL QUALIFIED DISPOSAL COMPANIES. SPECIAL SHIPPING INFORMATION: FOLLOW ALL TOG REGULATIONS AND SEE CLASSIFICATION IN SECTION I I SECTION IX PREPARATION INFORMATION PREPARED BY: TECHNICAL AFFAIRS DEPARTMENT, BDH INC.|, TORG260255-8521 ONTARIO REVISION DATE: OCT 7, 1991; JULY 4, 1994; MAY 26, DATE: JAN 12 1990 11995; NOVEMBER 5, 1995; NDV 17, 1995 WHMIS CLASSIFICATION: D1B, DZB, DZA •.. THE STATEMENTS CONTAINED HEREIN ARE OFFERED FOR INFORMATIONAL PURPOSES ONLY ANO AT THEIR MD SERE TOM PRO ENSE% INCE EONE ONE SAD MANNER SR UST HAD COPYRIGHT BDH, 1996 "ISSUED BY VWR 09+10-97" R04586 PAGE: 4 •#